DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and gpr22a

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_005164527.1	Gene:	gpr22a / 504167	ZFINID:	ZDB-GENE-041210-48	Length:	460	Species:	Danio rerio

Alignment Length:	384	Identity:	79/384 - (20%)
Similarity:	158/384 - (41%)	Gaps:	93/384 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 VDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAV-VLRAPRMRTVTNYFIVNLAIADIL 256
            :||..|....:.::..:......::..::||..|..|:|: .:::..:.:|:|...:||.:.|:|
Zfish    55 LDFEMDLKTPYPVSFQVSLTGFLMLEIVLGLSSNLTVLALYCMKSNLVSSVSNIVTMNLHVLDVL 119

  Fly   257 VIVFCLPATLI-------GNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRF-IAIWWP 313
            |.|.|:|.|::       ||       ..|:|.|.......:..|:..:::|::|||: |::...
Zfish   120 VCVGCIPLTIVVVLLPLEGN-------NALICCFHEACVSFASVATAANVLAITLDRYDISVRPA 177

  Fly   314 LKQMTKRRARIMIIGIWVIALVTTIPWLLFFD-LVP-AEEVFSDALVSAYSQPQFLCQEVWPPGT 376
            .:.:|..||..::..||.::         ||. ||| .||.|.....:..:|     .|...|..
Zfish   178 NRVLTMGRAVALLGSIWALS---------FFSFLVPFIEEGFFSQAGNERNQ-----TEAEEPSN 228

  Fly   377 D-----GNLYFLLANLVACYLLPMSLITLCYVLIW---IKVSTR--SIP---------------- 415
            :     |..|.|||.:...:...:.::...|.::.   |::.||  |:|
Zfish   229 EYYTELGLYYHLLAQIPIFFFTAVVMLVTYYKILQALNIRIGTRFHSVPKKKPRKKKTISMTSTQ 293

  Fly   416 GESKDAQMD---------------------------RMQQKSKVKVIKMLVAVVILFVLSWLPLY 453
            .||.||...                           |.:::.:.:|.:|.:.::..|:|.|.|:.
Zfish   294 PESTDASQSSAGRNAPLGMRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPIT 358

  Fly   454 VIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSR 512
            |:...|   ..:....|.:..::..:....|:  :..:|:||:..   |:.|..::||:
Zfish   359 VLNTVI---LSVGPSNFTVRLRLGFLVMAYGT--TIFHPLLYAFT---RQKFQKVLKSK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	61/290 (21%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	68/333 (20%)
gpr22a	XP_005164527.1	7tm_classA_rhodopsin-like	73..398	CDD:320086	72/350 (21%)
		TM helix 1	73..98	CDD:320086	5/24 (21%)
		TM helix 2	106..132	CDD:320086	10/25 (40%)
		TM helix 3	144..174	CDD:320086	8/29 (28%)
		TM helix 4	185..204	CDD:320086	7/27 (26%)
		TM helix 5	232..260	CDD:320086	5/27 (19%)
		TM helix 6	334..364	CDD:320086	7/29 (24%)
		TM helix 7	374..398	CDD:320086	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100