Protein Alignment SIFaR and OPRK1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 114/446 - (25%)
• Similarity: 205/446 - (45%)
• Gaps: 89/446 - (19%)

  Fly   172 AAAATKSYNDSAL--RWEQLD-----GSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFV 229
            |.:|....|.||.  .|.:.|     ||.|...:|.: .|.|:.::....|.|||:|||:|||.|
Human    17 APSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAH-ISPAIPVIITAVYSVVFVVGLVGNSLV 80

  Fly   230 IAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAA 294
            :.|::|..:|:|.||.:|.|||:||.||.. .:|......:...|..|.::||.|..|...::..
Human    81 MFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFT 144

  Fly   295 SVYSLIAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWVIALVTTIPWLLF--------FDLVP 348
            |:::|..:|:||:||:..|:|.:   |..:|:|:.|.||:::....|..::.        .|::.
Human   145 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIE 209

  Fly   349 AEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKV-STR 412
            ....|.|   ..||         |     .:|:..:...:..:::|:.:|.:||.|:.::: |.|
Human   210 CSLQFPD---DDYS---------W-----WDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVR 257

  Fly   413 SIPG-ESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKV 476
            .:.| ..||..:.|        :.::::.||.:||:.|.|:: ||..::.....|.....:....
Human   258 LLSGSREKDRNLRR--------ITRLVLVVVAVFVVCWTPIH-IFILVEALGSTSHSTAALSSYY 313

  Fly   477 MPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYH 540
            ..:|  ||.:||.:|||||: :::.::|.|      |..|..|:
Human   314 FCIA--LGYTNSSLNPILYAFLDENFKRCF------RDFCFPLK--------------------- 349

  Fly   541 QNSSRKSPSSKGNAV---SYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQF 593
            ....|:|.|...|.|   :|:.:.:.:.:...::.:.|:.|        |.|..:|
Human   350 MRMERQSTSRVRNTVQDPAYLRDIDGMNKPVXLVVEMSSYS--------SSGREEF 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	86/309 (28%)
		TM helix 1	210..236	CDD:320124	12/25 (48%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	6/17 (35%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	10/24 (42%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	86/309 (28%)
		TM helix 1	61..87	CDD:320219	12/25 (48%)
		TM helix 2	94..120	CDD:320219	11/26 (42%)
		TM helix 3	131..161	CDD:320219	11/29 (38%)
		TM helix 4	173..195	CDD:320219	6/21 (29%)
		TM helix 5	223..252	CDD:320219	6/28 (21%)
		TM helix 6	267..297	CDD:320219	9/38 (24%)
		TM helix 7	309..334	CDD:320219	10/26 (38%)