Protein Alignment SIFaR and TkR86C

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 158/639 - (24%)
• Similarity: 275/639 - (43%)
• Gaps: 153/639 - (23%)

  Fly    98 NSAITDTLLGTVLTTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNL 162
            ||.:..||||::..|...       |||:::....                        .||.::
  Fly    24 NSIVNTTLLGSLNRTEVV-------SLLSSIIDNR------------------------DNLESI 57

  Fly   163 SPATTSLISA--AAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIG 225
            :.|...|...  .:.|:.|.   |.|||                   ..::.:.:.::..|.:.|
  Fly    58 NEAKDFLTECLFPSPTRPYE---LPWEQ-------------------KTIWAIIFGLMMFVAIAG 100

  Fly   226 NSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGV 290
            |..|:.:|.....||||||||::||:|||:|:.........|..:...|..|.:.|....::..|
  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANV 165

  Fly   291 SVAASVYSLIAVSLDRFIAIWWPLKQMTKRR-ARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFS 354
            :|:.||::|:|:|.||:|||..|||:.|.|| .||:::.||.::.|.:.|.||          :|
  Fly   166 TVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLL----------YS 220

  Fly   355 DALVSAY--SQPQFLCQEVWP----PGTDGNLYFLLANLVACYLLPMSLITLCYVL----IWIKV 409
            ..:...|  .:.:.:|..:||    |.:..:..:.|..||..|.:||.::.:||.|    :|
  Fly   221 SIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW--- 282

  Fly   410 STRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILK 474
            .:||| ||:.|.||:.|  |||.||::|.:|:|.:|.:.|||.::.|......:.::..::  ::
  Fly   283 GSRSI-GENTDRQMESM--KSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKY--VQ 342

  Fly   475 KVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCC--GRLRY-YDNVAIASSTTSTRK 535
            .:.....||..||:.:||::|. :||::|..|..||   .||  |..|: :|:   ..|..:.:.
  Fly   343 HMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRII---CCCCVGLTRHRFDS---PKSRLTNKN 401

  Fly   536 SSHYHQNSS--------RKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQ 592
            ||:.|....        ..||.:....::.:.:         .|.|....:|.:|.....|.:
  Fly   402 SSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQ---------TLTQPKPQTQLLLSHHSPHPT-- 455

  Fly   593 FLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEARRSA------GHGLN----DTL 647
                |.|:....|..:|...:        :..:|..:.|....:|||      |.|.|    :.:
  Fly   456 ----QPSAAETKSQWKRSTME--------TQIQQAPVTSSCREQRSAQQQQPPGSGTNRAAVECI 508

  Fly   648 VDRD----------SVSMDVGRRQGATPSSLLDKRQKFVKQDSVISFVDQRPEQ 691
            ::|.          |::..:|.||..        :.|::..|...:.|:..|:|
  Fly   509 MERPADGSSSPLCLSINNSIGERQRV--------KIKYISCDEDNNPVELSPKQ 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	97/307 (32%)
		TM helix 1	210..236	CDD:320124	5/25 (20%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	12/29 (41%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	13/29 (45%)
		TM helix 7	474..498	CDD:320124	7/24 (29%)
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	97/307 (32%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	11/25 (44%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	6/20 (30%)
		TM helix 5	251..280	CDD:320512	9/28 (32%)
		TM helix 6	299..329	CDD:320512	13/29 (45%)
		TM helix 7	342..367	CDD:320512	7/24 (29%)