Protein Alignment SIFaR and Hcrtr2

DIOPT Version :9

• Sequence 1: NP_001163674.1
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_945200.1
• Gene: Hcrtr2 / 387285
• MGIID: 2680765
• Length: 460
• Species: Mus musculus
• Alignment Length: 462
• Identity: 139/462 - (30%)
• Similarity: 214/462 - (46%)
• Gaps: 86/462 - (18%)

  Fly   144 SLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSA-LR--WEQLDGSVDFGFDPLYRHSL 205
            |..:.|:.|...:|:...|:......::..    .|:|.. ||  |.:            |.|..
Mouse     3 STKLEDSLSRRNWSSASELNETQEPFLNPT----DYDDEEFLRYLWRE------------YLHPK 51

  Fly   206 AMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNI 270
            ....|....||:||:|.||||..|...|.:...||||||||||||::||:||.:.||||||:.:|
Mouse    52 EYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDI 116

  Fly   271 FVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIAL 334
            ...|..|..:||.:||:|.|||:.||.:|..::|||:.||..||. :.|.:|||..|:.||:::.
Mouse   117 TETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSC 181

  Fly   335 VTTIPWLLFFD-------LVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYL 392
            :..||..:..:       |.....:|:            :|.|.|.......:|.:...||. |:
Mouse   182 IIMIPQAIVMECSSMLPGLANKTTLFT------------VCDEHWGGEVYPKMYHICFFLVT-YM 233

  Fly   393 LPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQ---------------------------KS 430
            .|:.|:.|.|:.|:.|:..|.|||.|...|....||                           ::
Mouse   234 APLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRA 298

  Fly   431 KVKVIKMLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPI 493
            :.|..:||:.|:::|.:.:||:.:  :..|: ||.....|:.|.:......:.||..:||..|||
Mouse   299 RRKTARMLMVVLLVFAICYLPISILNVLKRV-FGMFTHTEDRETVYAWFTFSHWLVYANSAANPI 362

  Fly   494 LYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPS---SKGNA 554
            :|: ::.|:|..|.|..   |||..:.:.....:|...|||         .||||.:   |..:.
Mouse   363 IYNFLSGKFREEFKAAF---SCCLGVHHRQGDRLARGRTST---------ESRKSLTTQISNFDN 415

  Fly   555 VSYIYEH 561
            ||.:.||
Mouse   416 VSKLSEH 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	89/261 (34%)
		7tm_1	225..495	CDD:278431	98/306 (32%)
Hcrtr2	NP_945200.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		6/27 (22%)
		7tm_4	65..>194	CDD:304433	60/128 (47%)
		7tm_1	71..364	CDD:278431	98/306 (32%)
		Orexin_rec2	386..443	CDD:281778	13/46 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8802
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840