DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and Lkr

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster


Alignment Length:520 Identity:153/520 - (29%)
Similarity:241/520 - (46%) Gaps:83/520 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 RWEQLDGSVDFG-FDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIV 248
            |.|.|.|:.:.. |:.||.....:..:..:.|..:.:|.:|||:.||.||....:||||||.:|.
  Fly    11 RLEFLPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIA 75

  Fly   249 NLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWP 313
            |||.||:::.:||:|......:...|.|.|.||.|.|::|.:||..||::|.|:::||..||..|
  Fly    76 NLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINP 140

  Fly   314 LK-QMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTD 377
            |: :.||..::.:|.|||::||:..:|:.:.|.:....|.|.:. ...|:..:..|..  ...:|
  Fly   141 LRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFREN-NETYNVTRPFCMN--KNLSD 202

  Fly   378 GNLYFLLANLV-ACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAV 441
            ..|......|| ..||:|..:|:..|:.:.:::.....||.::|:: |....|:|.||||||:.|
  Fly   203 DQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSR-DITLLKNKKKVIKMLIIV 266

  Fly   442 VILFVLSWLP------LYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYSV-NK 499
            ||:|.|.|||      |||....|        .::..:..|.....||..||||.||.:|.: |:
  Fly   267 VIIFGLCWLPLQLYNILYVTIPEI--------NDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNE 323

  Fly   500 KYRRGF-----AAIIKSR-SCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKG------ 552
            |::|.|     |...|.: |.....|.:.....|||..||..:|.....|:...|:..|      
  Fly   324 KFKREFNKRFAACFCKFKTSMDAHERTFSMHTRASSIRSTYANSSMRIRSNLFGPARGGVNNGKP 388

  Fly   553 ----------NAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSCS-DASG 606
                      .|.|.||..:|        .|::|::.|       |...|.::...::.. .|.|
  Fly   389 GLHMPRVHGSGANSGIYNGSS--------GQNNNVNGQ-------HHQHQSVVTFAATPGVSAPG 438

  Fly   607 I-------RR----PL------CQQDSNGSKVSLSKQDSIVSYMEARRSAGHGLNDTLVDRDSVS 654
            :       ||    ||      |:.|     |:|.:..|.....| ..::|.|:...|:.|:|.|
  Fly   439 VGVAMPPWRRNNFKPLHPNVIECEDD-----VALMELPSTTPPSE-ELASGAGVQLALLSRESSS 497

  Fly   655  654
              Fly   498  497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 104/304 (34%)
TM helix 1 210..236 CDD:320124 9/25 (36%)
TM helix 2 243..269 CDD:320124 11/25 (44%)
TM helix 3 281..311 CDD:320124 13/29 (45%)
TM helix 4 322..340 CDD:320124 6/17 (35%)
TM helix 5 379..404 CDD:320124 8/25 (32%)
TM helix 6 429..459 CDD:320124 19/35 (54%)
TM helix 7 474..498 CDD:320124 10/24 (42%)
LkrNP_647968.3 7tmA_leucokinin-like 36..329 CDD:320515 104/304 (34%)
TM helix 1 37..63 CDD:320515 9/25 (36%)
TM helix 2 70..95 CDD:320515 11/24 (46%)
TM helix 3 108..138 CDD:320515 13/29 (45%)
TM helix 4 149..170 CDD:320515 7/20 (35%)
TM helix 5 205..234 CDD:320515 8/28 (29%)
TM helix 6 254..284 CDD:320515 16/29 (55%)
TM helix 7 297..322 CDD:320515 10/24 (42%)

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