Protein Alignment SIFaR and CCHa1-R

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 126/508 - (24%)
• Similarity: 225/508 - (44%)
• Gaps: 115/508 - (22%)

  Fly    61 NFVDLQNLLSFNELNGTSGSGGTAVSSLGSSSAIKLNNSAITDTLLGTVLTTATATVAPAASSLL 125
            |.|.::..|:.|....|||...||:..:.:          :|:||....:..:.:|..|
  Fly     4 NLVSMETDLAMNIGLDTSGEAPTALPPMPN----------VTETLWDLAMVVSQSTQWP------ 52

  Fly   126 ATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLD 190
                                 :.|..||..:|.|:     ||.        ..|
  Fly    53 ---------------------LLDTGSSENFSELV-----TTE--------TPY----------- 72

  Fly   191 GSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADI 255
              |.:|..|       .:.:..:.:.::|:||::||..:|.|.|...:||.|.|.:|::||:||:
  Fly    73 --VPYGRRP-------ETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADL 128

  Fly   256 LVIVFCLPATLIGNIFVP--WMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMT 318
            |||:..:|  |...::..  |..|..:|....:::.||:..||::|.|:|.||:.||..||::..
  Fly   129 LVIITTVP--LASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFH 191

  Fly   319 K----RRARIM----IIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPG 375
            .    |||..|    .:.||::|::..:|.|:..:|... .:...::|..|..|     |.|  |
  Fly   192 AHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHL-GINEKSIVICYPYP-----EEW--G 248

  Fly   376 TDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVS-TRSIPGESKDAQMDRMQQKSKVKVIKMLV 439
            .:.....:|.:.:..|.:|:.:|.:.||||.:.:. :.|:|||.:.|.   .|.:::.||...::
  Fly   249 INYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAV---RQVRARRKVAVTVL 310

  Fly   440 AVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMP-VAQWLGSSNSCINPI-LYSVNKKYR 502
            |.|::|.:.:||.:|.|....|. ..:|:::.....|:. ||..:..:|||.||: ||.|:..:|
  Fly   311 AFVVIFGICFLPYHVFFLWFYFW-PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFR 374

  Fly   503 RGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSH----YHQNSSRKSPSSK 551
            :.|...:..|...||.:              ::..|    .|:::|..|.:||
  Fly   375 KHFNRYLFCRGASGRRK--------------KRGQHDTFCMHRDTSLTSTASK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	91/308 (30%)
		TM helix 1	210..236	CDD:320124	8/25 (32%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	5/21 (24%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	9/29 (31%)
		TM helix 7	474..498	CDD:320124	10/25 (40%)
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	91/308 (30%)
		TM helix 1	83..109	CDD:320593	8/25 (32%)
		TM helix 2	116..142	CDD:320593	11/27 (41%)
		TM helix 3	154..184	CDD:320593	11/29 (38%)
		TM helix 4	201..221	CDD:320593	4/19 (21%)
		TM helix 5	252..277	CDD:320593	5/24 (21%)
		TM helix 6	300..330	CDD:320593	9/29 (31%)
		TM helix 7	345..370	CDD:320593	10/24 (42%)