Protein Alignment SIFaR and oprk1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001305709.1
• Gene: oprk1 / 360139
• ZFINID: ZDB-GENE-030729-1
• Length: 404
• Species: Danio rerio
• Alignment Length: 408
• Identity: 108/408 - (26%)
• Similarity: 189/408 - (46%)
• Gaps: 80/408 - (19%)

  Fly   200 LYRHSL---------AMS---MVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAI 252
            :|..||         |||   .:....|.|||:|||:||..|:.|::|..:|:|.||.:|.|||:
Zfish    35 IYNSSLNESWTTEQEAMSPLIPIITAVYSVVFVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLAV 99

  Fly   253 ADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM 317
            ||.||.. .:|......:...|..|.::||....|...::..|:::|..:|:||::|:..|:|.:
Zfish   100 ADALVTT-TMPFQSTDYLLNSWPFGEVVCKVFISIDYYNMFTSIFTLTMMSVDRYVAVCHPVKAL 163

  Fly   318 ---TKRRARIMIIGIWVIALVTTIPWLLFFDL------------VPAEEVFSDALVSAYSQPQFL 367
               |..:|:|:.|.|||::....||.::....            .|...|:.|.|:.       :
Zfish   164 DFRTPMKAKIINILIWVLSSAAGIPAMVLGSTQTNNGTTECALQFPDPYVYWDTLMK-------I 221

  Fly   368 CQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKV-STRSIPG-ESKDAQMDRMQQKS 430
            |            .|:..     ::.|:.:||:||.|:.::: |.|.:.| ..||..:.|
Zfish   222 C------------VFIFG-----FVAPLLIITVCYTLMVLRLKSVRLLSGSREKDRNLRR----- 264

  Fly   431 KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKK-VMPVAQWLGSSNSCINPIL 494
               :.::::.||.:||:.|.|:: ||..:|..|....|...::.. ...||  ||.:||.:||||
Zfish   265 ---ITRLVLVVVAVFVVCWTPIH-IFILVKALSHGVPETTSVMAAYFFCVA--LGYTNSSLNPIL 323

  Fly   495 YS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYI 558
            |: :::.::|.|...     ||......|...::...::.|:   :...:..|:...:|..|...
Zfish   324 YAFLDENFKRCFRDF-----CCPGRTAGDGRGVSRVRSTLRE---HTCPAEAKNDGGQGRPVXLA 380

  Fly   559 YEHNSLRRHNMMLKQDSN 576
            .|.:|.  |.   ::|||
Zfish   381 VELSSF--HG---REDSN 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	88/314 (28%)
		TM helix 1	210..236	CDD:320124	11/25 (44%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	9/29 (31%)
		TM helix 4	322..340	CDD:320124	7/17 (41%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	11/25 (44%)
oprk1	NP_001305709.1	7tmA_Kappa_opioid_R	56..335	CDD:320219	88/314 (28%)
		TM helix 1	57..83	CDD:320219	11/25 (44%)
		TM helix 2	90..116	CDD:320219	11/26 (42%)
		TM helix 3	127..157	CDD:320219	9/29 (31%)
		TM helix 4	169..191	CDD:320219	8/21 (38%)
		TM helix 5	216..245	CDD:320219	10/52 (19%)
		TM helix 6	260..290	CDD:320219	9/38 (24%)
		TM helix 7	303..328	CDD:320219	11/26 (42%)