Protein Alignment SIFaR and HCRTR2

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_016866287.1
• Gene: HCRTR2 / 3062
• HGNCID: 4849
• Length: 461
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 123/380 - (32%)
• Similarity: 188/380 - (49%)
• Gaps: 64/380 - (16%)

  Fly   201 YRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPAT 265
            |.|......|....||:||:|.||||..|...|.:...||||||||||||::||:||.:.|||||
Human    47 YLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPAT 111

  Fly   266 LIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGI 329
            |:.:|...|..|..:||.:||:|.|||:.||.:|..::|||:.||..||. :.|.:|||..|:.|
Human   112 LVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVII 176

  Fly   330 WVIALVTTIPWLL-------FFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLY---FLL 384
            |:::.:..||..:       |..|.....:|:            :|.|.|    .|.:|   :.:
Human   177 WIVSCIIMIPQAIVMECSTVFPGLANKTTLFT------------VCDERW----GGEIYPKMYHI 225

  Fly   385 ANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQ-------------------MDRM---- 426
            ...:..|:.|:.|:.|.|:.|:.|:..|.|||.|...|                   ..||
Human   226 CFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVA 290

  Fly   427 ----QQKSKVKVIKMLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGS 485
                |.:::.|..:||:.|:::|.:.:||:.:  :..|: ||.....|:.|.:......:.||..
Human   291 AEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRV-FGMFAHTEDRETVYAWFTFSHWLVY 354

  Fly   486 SNSCINPILYS-VNKKYRRGFAAIIKSRSCC---GRLRYYDNVAIASSTTSTRKS 536
            :||..|||:|: ::.|:|..|.|..   |||   ...|..|.:....::|.:|||
Human   355 ANSAANPIIYNFLSGKFREEFKAAF---SCCCLGVHHRQEDRLTRGRTSTESRKS 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	110/336 (33%)
		TM helix 1	210..236	CDD:320124	12/25 (48%)
		TM helix 2	243..269	CDD:320124	18/25 (72%)
		TM helix 3	281..311	CDD:320124	15/29 (52%)
		TM helix 4	322..340	CDD:320124	6/17 (35%)
		TM helix 5	379..404	CDD:320124	6/27 (22%)
		TM helix 6	429..459	CDD:320124	7/31 (23%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
HCRTR2	XP_016866287.1	7tmA_OXR	55..375	CDD:320336	110/336 (33%)
		TM helix 1	56..82	CDD:320336	12/25 (48%)
		TM helix 2	89..115	CDD:320336	18/25 (72%)
		TM helix 3	127..157	CDD:320336	15/29 (52%)
		TM helix 4	168..189	CDD:320336	8/20 (40%)
		TM helix 5	220..249	CDD:320336	6/28 (21%)
		TM helix 6	297..327	CDD:320336	7/29 (24%)
		TM helix 7	343..368	CDD:320336	8/24 (33%)
		Orexin_rec2	387..444	CDD:427531	6/20 (30%)