DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and HCRTR1

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001516.2 Gene:HCRTR1 / 3061 HGNCID:4848 Length:425 Species:Homo sapiens


Alignment Length:430 Identity:132/430 - (30%)
Similarity:200/430 - (46%) Gaps:89/430 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVT 243
            |.|..||:...|          |.:......|...||:.||:|.|:||:.|...|.|...|||||
Human    27 YEDEFLRYLWRD----------YLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVT 81

  Fly   244 NYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFI 308
            |||||||::||:||...||||:|:.:|...|:.|..:||.:||:|.|||:.:|.:|..::|||:.
Human    82 NYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWY 146

  Fly   309 AIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFF-------DLVPAEEVFSDALVSAYSQPQ 365
            ||..||. :.|.||||..|:|||.::|...:|.....       :|.....:||           
Human   147 AICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFS----------- 200

  Fly   366 FLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESK---------DA 421
             :|.|.|.......:|.....:|. ||.|:.|:.:.|..|:.|:..|.|||.:.         ..
Human   201 -VCDERWADDLYPKIYHSCFFIVT-YLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSD 263

  Fly   422 QMDRMQQ--------------------KSKVKVIKMLVAVVILFVLSWLPLYV--IFARIKFGSD 464
            |:..::|                    :::.|..|||:.|:::|.|.:||:.|  :..|: ||..
Human   264 QLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRV-FGMF 327

  Fly   465 ISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSC-------CGRLRYY 521
            ....:.|.:......:.||..:||..|||:|: ::.|:|..|.|..   ||       ||.|:  
Human   328 RQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF---SCCLPGLGPCGSLK-- 387

  Fly   522 DNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEH 561
                     ..:.:||..|::.|.:|..|    :|.|.||
Human   388 ---------APSPRSSASHKSLSLQSRCS----ISKISEH 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 109/335 (33%)
TM helix 1 210..236 CDD:320124 11/25 (44%)
TM helix 2 243..269 CDD:320124 17/25 (68%)
TM helix 3 281..311 CDD:320124 14/29 (48%)
TM helix 4 322..340 CDD:320124 7/17 (41%)
TM helix 5 379..404 CDD:320124 7/24 (29%)
TM helix 6 429..459 CDD:320124 10/31 (32%)
TM helix 7 474..498 CDD:320124 8/24 (33%)
HCRTR1NP_001516.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Required for response to orexin-A. /evidence=ECO:0000269|PubMed:26950369 26..41 6/23 (26%)
7tmA_OXR 47..369 CDD:320336 109/335 (33%)
TM helix 1 48..74 CDD:320336 11/25 (44%)
TM helix 2 81..107 CDD:320336 17/25 (68%)
TM helix 3 119..149 CDD:320336 14/29 (48%)
TM helix 4 160..181 CDD:320336 9/20 (45%)
TM helix 5 212..241 CDD:320336 8/29 (28%)
TM helix 6 291..321 CDD:320336 10/29 (34%)
TM helix 7 337..362 CDD:320336 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

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