Protein Alignment SIFaR and oprd1a

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_571333.2
• Gene: oprd1a / 30509
• ZFINID: ZDB-GENE-990415-199
• Length: 374
• Species: Danio rerio
• Alignment Length: 368
• Identity: 98/368 - (26%)
• Similarity: 184/368 - (50%)
• Gaps: 69/368 - (18%)

  Fly   205 LAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGN 269
            :|:|:.  ..|.|:.:|||:||..|:..|:|..:::|.||.:|.|||:||.|. ...||......
Zfish    52 IAISIT--ALYSVICVVGLLGNILVMYGVVRYTKLKTATNIYIFNLALADALA-TSTLPFQSTKY 113

  Fly   270 IFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWV 331
            :...|..|.|:||.|..|...::..|:::|..:|:||:||:..|::.:   |..:|:|:.:.||:
Zfish   114 LMNTWPFGELLCKVVIAIDYYNMFTSIFTLTMMSVDRYIAVCHPVRALEFRTPIKAKIINVCIWI 178

  Fly   332 IALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYF----LLANLVACYL 392
            ::....:|.::.            |:....:|...:|...:|   |.:.|:    .:...:..::
Zfish   179 LSSAVGVPIMIM------------AVTRVTNQNTTVCMLKFP---DPDWYWDTVTKICVFIFAFV 228

  Fly   393 LPMSLITLCYVLIWIKV-STRSIPG-ESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVI 455
            :|:.:||:||.|:.::: |.|.:.| :.||..|.|        :.:|::.||..|::.|.|:: |
Zfish   229 VPVLVITICYGLMILRLKSVRLLSGSKEKDRNMRR--------ITRMVLVVVAAFIICWTPIH-I 284

  Fly   456 FARIKFGSDISQEEFEILKKVMPVAQW-----LGSSNSCINPILYS-VNKKYRRGFAAIIKSRSC 514
            |..:|...||:|      |....:|.|     ||.:||.:||:||: :::.::|.|      |..
Zfish   285 FIIVKTLVDINQ------KNPFVIASWHLCIALGYTNSSLNPVLYAFLDENFKRCF------RDF 337

  Fly   515 CGRLRYYDNVAIASSTTSTRKSSHYHQNSSRK-----SPSSKG 552
            |...|          |.:.:.:.:..:|::|:     :||..|
Zfish   338 CLPFR----------TRADQSNLNRARNATREPVSVCAPSDTG 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	86/310 (28%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	4/17 (24%)
		TM helix 5	379..404	CDD:320124	6/28 (21%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	11/29 (38%)
oprd1a	NP_571333.2	7tmA_Delta_opioid_R	54..334	CDD:320217	87/312 (28%)
		TM helix 1	55..81	CDD:320217	10/27 (37%)
		TM helix 2	88..114	CDD:320217	11/26 (42%)
		TM helix 3	125..155	CDD:320217	11/29 (38%)
		TM helix 4	167..189	CDD:320217	5/21 (24%)
		TM helix 5	214..244	CDD:320217	6/29 (21%)
		TM helix 6	263..289	CDD:320217	9/34 (26%)
		TM helix 7	302..327	CDD:320217	10/24 (42%)