Protein Alignment SIFaR and Oprl1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 353
• Identity: 99/353 - (28%)
• Similarity: 170/353 - (48%)
• Gaps: 53/353 - (15%)

  Fly   186 WEQLDGSVDFGFDPLYR------------HS----LAMSMVYCVAYIVVFLVGLIGNSFVIAVVL 234
            ||.|.||...|...|..            ||    |.:.:.....|:.|.:.||:||..|:.|:|
  Rat    10 WEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVIL 74

  Fly   235 RAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSL 299
            |..:|:|.||.:|.|||:||.||:: .||......:...|..|..:||.|..|...::..|.::|
  Rat    75 RHTKMKTATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTL 138

  Fly   300 IAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWVIALVTTIPWLLFFDL-VPAEEVFSDALVSA 360
            .|:|:||::||..|::.:   |..:|:.:.:.||.:|.|..:|..:.... |..||:  :.||..
  Rat   139 TAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI--ECLVEI 201

  Fly   361 YSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKV-STRSIPG-ESKDAQM 423
            .:.     |:.|.|      .|.:...:..:::|:.:|::||.|:..:: ..|.:.| ..||..:
  Rat   202 PAP-----QDYWGP------VFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNL 255

  Fly   424 DRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNS 488
            .|        :.::::.||.:||..|.|:.| |..:: |..: |...|....::.....||..||
  Rat   256 RR--------ITRLVLVVVAVFVGCWTPVQV-FVLVQ-GLGV-QPGSETAVAILRFCTALGYVNS 309

  Fly   489 CINPILYS-VNKKYRRGFAAIIKSRSCC 515
            |:|||||: :::.::..|     .:.||
  Rat   310 CLNPILYAFLDENFKACF-----RKFCC 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	86/302 (28%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	10/24 (42%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	86/302 (28%)
		TM helix 1	50..76	CDD:320220	9/25 (36%)
		TM helix 2	83..109	CDD:320220	12/26 (46%)
		TM helix 3	120..150	CDD:320220	11/29 (38%)
		TM helix 4	162..184	CDD:320220	6/21 (29%)
		TM helix 5	209..238	CDD:320220	7/34 (21%)
		TM helix 6	253..283	CDD:320220	9/38 (24%)
		TM helix 7	295..320	CDD:320220	10/24 (42%)