Protein Alignment SIFaR and GRPR

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 107/362 - (29%)
• Similarity: 179/362 - (49%)
• Gaps: 36/362 - (9%)

  Fly   192 SVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADIL 256
            |.|...:..:.|...:.::..| |.|:.|:|||||..:|.:......||.|.|.||.:||:.|:|
Human    25 SADLPVNDDWSHPGILYVIPAV-YGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLL 88

  Fly   257 VIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKR 320
            :::.|.|......:...|:.|.:.||.:|:||..||..||::|.|:|.||:.||..|:. |.:..
Human    89 LLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHA 153

  Fly   321 RARIMIIG--IWVIALVTTIPWLLFFDLVP-AEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYF 382
            ..:|.:..  ||:|:::..||..:|.||.| .||..:...:|....|.  ..|:.|.      ..
Human   154 LMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPH--SNELHPK------IH 210

  Fly   383 LLANLVACYLLPMSLITLCYVLIWIKV--STRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILF 445
            .:|:.:..|::|:|:|::.|..|...:  |..::|.|.....  :.|.:|:.::.|.::..|.||
Human   211 SMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHV--KKQIESRKRLAKTVLVFVGLF 273

  Fly   446 VLSWLPLYVIFARIKFGSDISQEEFEILKKVMPV-AQWLGSSNSCINPI-LYSVNKKYRRGF--- 505
            ...|||.:||:....:  ..|:.:..:|..|..: |:.|..:|||:||. ||.::|.:|:.|
Human   274 AFCWLPNHVIYLYRSY--HYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQ 336

  Fly   506 ------AAIIKSRSCCGRLRYYDNVAIASSTTSTRKS 536
                  ..||:|.| .||     :....:|..||..|
Human   337 LLCCQPGLIIRSHS-TGR-----STTCMTSLKSTNPS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	93/303 (31%)
		TM helix 1	210..236	CDD:320124	10/25 (40%)
		TM helix 2	243..269	CDD:320124	9/25 (36%)
		TM helix 3	281..311	CDD:320124	15/29 (52%)
		TM helix 4	322..340	CDD:320124	5/19 (26%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	10/29 (34%)
		TM helix 7	474..498	CDD:320124	10/25 (40%)
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	93/304 (31%)
		TM helix 1	42..68	CDD:320252	10/26 (38%)
		TM helix 2	75..101	CDD:320252	9/25 (36%)
		TM helix 3	113..143	CDD:320252	15/29 (52%)
		TM helix 4	155..175	CDD:320252	5/19 (26%)
		TM helix 5	207..232	CDD:320252	7/30 (23%)
		TM helix 6	257..287	CDD:320252	10/29 (34%)
		TM helix 7	301..326	CDD:320252	10/24 (42%)