Protein Alignment SIFaR and GPR22

DIOPT Version :9

• Sequence 1: NP_001163674.1
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_005286.2
• Gene: GPR22 / 2845
• HGNCID: 4477
• Length: 433
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 89/447 - (19%)
• Similarity: 184/447 - (41%)
• Gaps: 106/447 - (23%)

  Fly   197 FDPL-YRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVV--LRAPRMRTVTNYFIVNLAIADILVI 258
            :.|| |..|..:|:   ..::::.:|..:|::..:.|:  :::..:.:|:|...:||.:.|:::.
Human    31 YQPLSYPLSFQVSL---TGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIIC 92

  Fly   259 VFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRF-IAIWWPLKQMTKRRA 322
            |.|:|.|::..:........|:|.|.......:..::..::.|::|||: |::....:.:|..||
Human    93 VGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRA 157

  Fly   323 RIMIIGIWVIALVTTIPWLLFFD-LVPAEEV--FSDALVSAYSQPQFLCQEVWPPGTD-GNLYFL 383
            .:::|.||:.:         ||. |:|..||  ||....:.:.....||.......|: |..|.|
Human   158 VMLMISIWIFS---------FFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHL 213

  Fly   384 LANL-VACYLLPMSLITLCYVL--IWIKVSTRSIPGESKDAQMDR------------MQQKS--- 430
            |..: :..:.:.:.|||...:|  :.|::.||...|:.|.|:..:            |.|.|
Human   214 LVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGR 278

  Fly   431 -----------------------------KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDIS 466
                                         :.:|.:|.:.::..|:|.|.|:.|:...|     :.
Human   279 NVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTI-----LC 338

  Fly   467 QEEFEILKKVMPVAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTT 531
            ....::|.|:......:....:..:|:||:..   |:.|..::||:.   :.|....|
Human   339 LGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFT---RQKFQKVLKSKM---KKRVVSIV------- 390

  Fly   532 STRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSL---RRHNMMLKQDSNLSQQMLLKQ 585
                          ::.....|||.    |||.   :|:..:..:||.:.::.|:.|
Human   391 --------------EADPLPNNAVI----HNSWIDPKRNKKITFEDSEIREKCLVPQ 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	56/280 (20%)
		7tm_1	225..495	CDD:278431	64/323 (20%)
GPR22	NP_005286.2	7tm_classA_rhodopsin-like	44..370	CDD:410626	67/342 (20%)
		TM helix 1	44..68	CDD:410626	3/26 (12%)
		TM helix 2	78..100	CDD:410626	7/21 (33%)
		TM helix 3	116..138	CDD:410626	2/21 (10%)
		TM helix 4	159..175	CDD:410626	6/24 (25%)
		TM helix 5	209..232	CDD:410626	6/22 (27%)
		TM helix 6	312..334	CDD:410626	6/21 (29%)
		TM helix 7	346..370	CDD:410626	4/23 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100