DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and PRLHR

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_004239.2 Gene:PRLHR / 2834 HGNCID:4464 Length:370 Species:Homo sapiens


Alignment Length:411 Identity:111/411 - (27%)
Similarity:184/411 - (44%) Gaps:104/411 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 ATATVAPAASSLLATL--AATTTA--SARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAA 173
            ::.|..|..|.|.:.|  |.||.|  ||..|....|:|.|||.:.|.:.:|        .|:   
Human     3 SSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSL--------QLV--- 56

  Fly   174 AATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPR 238
                         .||.|.:                  .:.|.||.:|||:||..::.|:.|..|
Human    57 -------------HQLKGLI------------------VLLYSVVVVVGLVGNCLLVLVIARVRR 90

  Fly   239 MRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVP--WMLGWLMCKFVPYIQGVSVAASVYSLIA 301
            :..|||:.|.|||::|:|:...|:|.|| ...|.|  |:.|..:|..|.::|.|:|..||::|..
Human    91 LHNVTNFLIGNLALSDVLMCTACVPLTL-AYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTT 154

  Fly   302 VSLDRFIAIWWPL-KQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYS--- 362
            :::||::.:..|| ::::.|.:...::.||.::.|..:|                |.|..|.   
Human   155 IAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALP----------------AAVHTYHVEL 203

  Fly   363 QPQ--FLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPG--ESKDAQM 423
            :|.  .||:|.|.........:....|:..||||:.:|.|.||.:.:|:..|.:||  ....|..
Human   204 KPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADW 268

  Fly   424 DRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMP---------- 478
            ||.:::   :...:||.:|::|.:.||||:|               |.:|:.:.|          
Human   269 DRARRR---RTFCLLVVIVVVFAVCWLPLHV---------------FNLLRDLDPHAIDPYAFGL 315

  Fly   479 ---VAQWLGSSNSCINPILYS 496
               :..||..|::|.||.:|:
Human   316 VQLLCHWLAMSSACYNPFIYA 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 88/311 (28%)
TM helix 1 210..236 CDD:320124 9/25 (36%)
TM helix 2 243..269 CDD:320124 12/25 (48%)
TM helix 3 281..311 CDD:320124 10/29 (34%)
TM helix 4 322..340 CDD:320124 3/17 (18%)
TM helix 5 379..404 CDD:320124 8/24 (33%)
TM helix 6 429..459 CDD:320124 9/29 (31%)
TM helix 7 474..498 CDD:320124 8/36 (22%)
PRLHRNP_004239.2 TM helix 4 175..196 CDD:320516 5/36 (14%)
TM helix 5 222..251 CDD:320516 9/28 (32%)
TM helix 6 271..301 CDD:320516 10/47 (21%)
TM helix 7 314..339 CDD:320516 7/23 (30%)
Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000269|PubMed:11641419 365..370
7tmA_PrRP_R 77..346 CDD:320516 82/295 (28%)
TM helix 2 95..120 CDD:320516 12/25 (48%)
TM helix 3 134..164 CDD:320516 10/29 (34%)
Blue background indicates that the domain is not in the aligned region.

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