Protein Alignment SIFaR and aexr-2

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001359893.1
• Gene: aexr-2 / 259709
• WormBaseID: WBGene00016090
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 410
• Identity: 92/410 - (22%)
• Similarity: 167/410 - (40%)
• Gaps: 74/410 - (18%)

  Fly   198 DPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVT-NYFIVNLAIADILVIVFC 261
            |...|.:.||..|    .|...|:..:.|..|||...:..:.:..| :.||:|:.|.|.::.:||
 Worm    47 DSFIRFATAMDDV----LIGACLISTVINFIVIACSAKLYKKKGDTLHLFILNMTIGDTILTLFC 107

  Fly   262 LPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ---MTKRRAR 323
            .|..|:...:....:.::.. |:.:...|.:|.|..||..:::|:.|...||.|.   |:..||:
 Worm   108 HPYELVTRRYSGAHVHFITV-FLNFANWVGLAVSGLSLTLLNIDKLIFFCWPFKYDIWMSYFRAK 171

  Fly   324 IMIIGIWVIAL-VTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGN-------- 379
            :.....|:|:: ..|..|:..:      ..|.:|.|..  |.||..|.|:..|...:
 Worm   172 LFCYLSWIISIGFATYYWMYSY------MYFVNATVDI--QQQFEIQFVFLTGLMNSGQFSPVNK 228

  Fly   380 LYFLLANLVACYLLPM--SLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVV 442
            :::.:..:|.| ::|:  ||:..||:....|...:::...|..::::     :|......:.|..
 Worm   229 IFYEVFTVVFC-VIPIVSSLLVSCYLYDLTKRKRKTVIKTSSASKIE-----NKATSFAFIFATT 287

  Fly   443 ILFVLSWLPLYVI-FARIKF--GSDISQEEFEILKKVMPVAQWLGSS-------NSCINPILYS- 496
            :....|.||..:. .|||..  ..::..|..:.|       .||..|       |..|||::.:
 Worm   288 LWTSCSLLPYRIANLARIHIIAWPNLDCESRQNL-------SWLTWSMLYLLILNPIINPLITAF 345

  Fly   497 VNKKYRRGFAAIIKSRSCCGRLRYYD------NVAIASSTTSTRKSSHY---------HQNSSRK 546
            ....||:...:.::..|   |..|.|      |.:..:||.|......|         |..:.||
 Worm   346 AYAPYRQMIYSRVRKSS---RKNYQDQNSYETNKSNITSTNSVSSKVFYVDLTMAKQNHTKTLRK 407

  Fly   547 SPSSKGNAV----SYIYEHN 562
            :|.:|..::    |::...|
 Worm   408 APLAKFPSICSCGSFVTNEN 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	72/321 (22%)
		TM helix 1	210..236	CDD:320124	7/25 (28%)
		TM helix 2	243..269	CDD:320124	10/26 (38%)
		TM helix 3	281..311	CDD:320124	8/29 (28%)
		TM helix 4	322..340	CDD:320124	4/18 (22%)
		TM helix 5	379..404	CDD:320124	7/34 (21%)
		TM helix 6	429..459	CDD:320124	6/30 (20%)
		TM helix 7	474..498	CDD:320124	7/31 (23%)
aexr-2	NP_001359893.1	7tm_classA_rhodopsin-like	59..342	CDD:410626	70/308 (23%)
		TM helix 1	59..82	CDD:410626	7/26 (27%)
		TM helix 2	89..115	CDD:410626	9/25 (36%)
		TM helix 3	126..156	CDD:410626	8/30 (27%)
		TM helix 4	169..188	CDD:410626	5/18 (28%)
		TM helix 5	227..248	CDD:410626	4/21 (19%)
		TM helix 6	274..304	CDD:410626	5/34 (15%)
		TM helix 7	322..342	CDD:410626	7/19 (37%)