Protein Alignment SIFaR and GALR1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001471.2
• Gene: GALR1 / 2587
• HGNCID: 4132
• Length: 349
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 97/356 - (27%)
• Similarity: 162/356 - (45%)
• Gaps: 68/356 - (19%)

  Fly   208 SMVYCVAYIVVFLVGLIGNSFVIAVVLRAP--RMRTVTNYFIVNLAIADILVIVFCLPATLIGNI 270
            :.|..|.:.::|.:|::|||.||.|:.|:.  :.|:.||.||:||:|||:..::||:|.......
Human    33 NFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYA 97

  Fly   271 FVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRRARIMIIG---IWVI 332
            ...|:||..:|||:.|...||:..|:::|.|:|:||::||....:..:.|.:|..::|   ||.:
Human    98 LPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWAL 162

  Fly   333 ALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSL 397
            ::....|           ..:...|....:..|..|.|.||.......| ::...|..||||:.|
Human   163 SIAMASP-----------VAYHQGLFHPRASNQTFCWEQWPDPRHKKAY-VVCTFVFGYLLPLLL 215

  Fly   398 ITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFG 462
            |..||..:...:       ..|...|.:..:.||.|..:.::.||::|.:||||.::|....:||
Human   216 ICFCYAKVLNHL-------HKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFG 273

  Fly   463 SDISQEEFEILKKVMPV----------AQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCG 516
                         |.|:          |..|..|||.:|||:|: :::.:|:.:..:.|..
Human   274 -------------VFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCH---- 321

  Fly   517 RLRYYDNVAIASSTTSTRKSSHYHQNSSRKS 547
                            .||.||.......||
Human   322 ----------------IRKDSHLSDTKESKS 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	90/311 (29%)
		TM helix 1	210..236	CDD:320124	10/25 (40%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	4/20 (20%)
		TM helix 5	379..404	CDD:320124	10/24 (42%)
		TM helix 6	429..459	CDD:320124	11/29 (38%)
		TM helix 7	474..498	CDD:320124	11/34 (32%)
GALR1	NP_001471.2	7tmA_Gal1_R	34..314	CDD:320226	90/311 (29%)
		TM helix 1	35..61	CDD:320226	10/25 (40%)
		TM helix 2	70..96	CDD:320226	12/25 (48%)
		TM helix 3	108..138	CDD:320226	13/29 (45%)
		TM helix 4	150..170	CDD:320226	5/30 (17%)
		TM helix 5	197..226	CDD:320226	10/29 (34%)
		TM helix 6	240..270	CDD:320226	11/29 (38%)
		TM helix 7	282..307	CDD:320226	9/24 (38%)