DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and Oprm1

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001033690.1 Gene:Oprm1 / 25601 RGDID:3234 Length:468 Species:Rattus norvegicus


Alignment Length:410 Identity:113/410 - (27%)
Similarity:201/410 - (49%) Gaps:63/410 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 PATTSLISAAAATKSYNDSALRW---EQLDGSVD----------FGFDPLYRHSLAMSMVYCVA- 214
            |..||..|...|..|.:.:...|   ..:||:..          .|.|.|...:.:.|||..:. 
  Rat     7 PGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITI 71

  Fly   215 ---YIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWML 276
               |.:|.:|||.||..|:.|::|..:|:|.||.:|.|||:||.|. ...||...:..:...|..
  Rat    72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPF 135

  Fly   277 GWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWVIALVTTI 338
            |.::||.|..|...::..|:::|..:|:||:||:..|:|.:   |.|.|:|:.:..|:::....:
  Rat   136 GTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL 200

  Fly   339 PWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYV 403
            | ::|.......:...|..:: :|.|.:    .|.     ||..:...:.| :::|:.:||:||.
  Rat   201 P-VMFMATTKYRQGSIDCTLT-FSHPTW----YWE-----NLLKICVFIFA-FIMPVLIITVCYG 253

  Fly   404 LIWIKV-STRSIPG-ESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDIS 466
            |:.::: |.|.:.| :.||..:.|        :.:|::.||.:|::.|.|:: |:..||....|.
  Rat   254 LMILRLKSVRMLSGSKEKDRNLRR--------ITRMVLVVVAVFIVCWTPIH-IYVIIKALITIP 309

  Fly   467 QEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASST 530
            :..|:.:.....:|  ||.:|||:||:||: :::.::|.|      |..|         ...|||
  Rat   310 ETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF------REFC---------IPTSST 357

  Fly   531 TSTRKSSHYHQNSSRKSPSS 550
            ...:.|:...|| :|:.||:
  Rat   358 IEQQNSTRVRQN-TREHPST 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 88/305 (29%)
TM helix 1 210..236 CDD:320124 10/29 (34%)
TM helix 2 243..269 CDD:320124 11/25 (44%)
TM helix 3 281..311 CDD:320124 11/29 (38%)
TM helix 4 322..340 CDD:320124 3/17 (18%)
TM helix 5 379..404 CDD:320124 8/24 (33%)
TM helix 6 429..459 CDD:320124 7/29 (24%)
TM helix 7 474..498 CDD:320124 10/24 (42%)
Oprm1NP_001033690.1 7tmA_Mu_opioid_R 69..347 CDD:320218 86/301 (29%)
TM helix 1 70..96 CDD:320218 9/25 (36%)
TM helix 2 103..129 CDD:320218 11/26 (42%)
TM helix 3 140..170 CDD:320218 11/29 (38%)
TM helix 4 182..204 CDD:320218 5/22 (23%)
TM helix 5 229..258 CDD:320218 9/34 (26%)
TM helix 6 273..303 CDD:320218 8/38 (21%)
TM helix 7 315..340 CDD:320218 10/26 (38%)
NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000250|UniProtKB:P42866 332..336 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 361..385 6/17 (35%)

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