DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and Hcrtr1

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_037196.1 Gene:Hcrtr1 / 25593 RGDID:2787 Length:416 Species:Rattus norvegicus


Alignment Length:453 Identity:135/453 - (29%)
Similarity:204/453 - (45%) Gaps:101/453 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LSPATTSLISAAAATKS---------YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIV 217
            :.|:.|........|.|         |.|..||:...|          |.:......|...||:.
  Rat     1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRD----------YLYPKQYEWVLIAAYVA 55

  Fly   218 VFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCK 282
            |||:.|:||:.|...|.|...||||||||||||::||:||...||||:|:.:|...|:.|..:||
  Rat    56 VFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK 120

  Fly   283 FVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFF-- 344
            .:||:|.|||:.:|.:|..::|||:.||..||. :.|.||||..|:|||.::|...:|.....  
  Rat   121 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMEC 185

  Fly   345 -----DLVPAEEVFSDALVSAYSQPQFLCQEVWP----PGTDGNLYFLLANLVACYLLPMSLITL 400
                 :|.....:||            :|.|.|.    |....:.:|.:.     ||.|:.|:.:
  Rat   186 SSVLPELANRTRLFS------------VCDERWADELYPKIYHSCFFFVT-----YLAPLGLMGM 233

  Fly   401 CYVLIWIKVSTRSIPG-------------ESKDAQMDRM----------------QQKSKVKVIK 436
            .|..|:.|:....|||             |..:||...:                |.:::.|..|
  Rat   234 AYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAK 298

  Fly   437 MLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VN 498
            ||:.|:::|.|.:||:.|  :..|: ||......:.|.:......:.||..:||..|||:|: ::
  Rat   299 MLMVVLLVFALCYLPISVLNVLKRV-FGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362

  Fly   499 KKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEH 561
            .|:|..|.|..   |||        :.....::|.|     |::.|.:|..|    ||.:.||
  Rat   363 GKFREQFKAAF---SCC--------LPGLGPSSSAR-----HKSLSLQSRCS----VSKVSEH 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 110/339 (32%)
TM helix 1 210..236 CDD:320124 11/25 (44%)
TM helix 2 243..269 CDD:320124 17/25 (68%)
TM helix 3 281..311 CDD:320124 14/29 (48%)
TM helix 4 322..340 CDD:320124 7/17 (41%)
TM helix 5 379..404 CDD:320124 6/24 (25%)
TM helix 6 429..459 CDD:320124 10/31 (32%)
TM helix 7 474..498 CDD:320124 8/24 (33%)
Hcrtr1NP_037196.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 4/20 (20%)
Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613 26..41 6/24 (25%)
7tmA_OXR 47..369 CDD:320336 110/339 (32%)
TM helix 1 48..74 CDD:320336 11/25 (44%)
TM helix 2 81..107 CDD:320336 17/25 (68%)
TM helix 3 119..149 CDD:320336 14/29 (48%)
TM helix 4 160..181 CDD:320336 9/20 (45%)
TM helix 5 212..241 CDD:320336 8/33 (24%)
TM helix 6 291..321 CDD:320336 10/29 (34%)
TM helix 7 337..362 CDD:320336 8/24 (33%)

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