DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and Hcrtr1

DIOPT Version :9

Sequence 1:NP_001163674.1 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_037196.1 Gene:Hcrtr1 / 25593 RGDID:2787 Length:416 Species:Rattus norvegicus


Alignment Length:453 Identity:135/453 - (29%)
Similarity:204/453 - (45%) Gaps:101/453 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LSPATTSLISAAAATKS---------YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIV 217
            :.|:.|........|.|         |.|..||:...|          |.:......|...||:.
  Rat     1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRD----------YLYPKQYEWVLIAAYVA 55

  Fly   218 VFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCK 282
            |||:.|:||:.|...|.|...||||||||||||::||:||...||||:|:.:|...|:.|..:||
  Rat    56 VFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK 120

  Fly   283 FVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFF-- 344
            .:||:|.|||:.:|.:|..::|||:.||..||. :.|.||||..|:|||.::|...:|.....  
  Rat   121 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMEC 185

  Fly   345 -----DLVPAEEVFSDALVSAYSQPQFLCQEVWP----PGTDGNLYFLLANLVACYLLPMSLITL 400
                 :|.....:||            :|.|.|.    |....:.:|.:.     ||.|:.|:.:
  Rat   186 SSVLPELANRTRLFS------------VCDERWADELYPKIYHSCFFFVT-----YLAPLGLMGM 233

  Fly   401 CYVLIWIKVSTRSIPG-------------ESKDAQMDRM----------------QQKSKVKVIK 436
            .|..|:.|:....|||             |..:||...:                |.:::.|..|
  Rat   234 AYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAK 298

  Fly   437 MLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VN 498
            ||:.|:::|.|.:||:.|  :..|: ||......:.|.:......:.||..:||..|||:|: ::
  Rat   299 MLMVVLLVFALCYLPISVLNVLKRV-FGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362

  Fly   499 KKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEH 561
            .|:|..|.|..   |||        :.....::|.|     |::.|.:|..|    ||.:.||
  Rat   363 GKFREQFKAAF---SCC--------LPGLGPSSSAR-----HKSLSLQSRCS----VSKVSEH 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_001163674.1 7tm_4 216..>443 CDD:304433 88/267 (33%)
7tm_1 225..495 CDD:278431 100/312 (32%)
Hcrtr1NP_037196.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 4/20 (20%)
Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613 26..41 6/24 (25%)
7tmA_OXR 47..369 CDD:320336 110/339 (32%)
TM helix 1 49..73 CDD:320336 10/23 (43%)
TM helix 2 82..104 CDD:320336 15/21 (71%)
TM helix 3 120..142 CDD:320336 9/21 (43%)
TM helix 4 163..179 CDD:320336 5/15 (33%)
TM helix 5 213..236 CDD:320336 5/27 (19%)
TM helix 6 297..319 CDD:320336 9/21 (43%)
TM helix 7 337..362 CDD:320336 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166354580
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9048
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X258
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.840

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