Protein Alignment SIFaR and Tacr3

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_058749.1
• Gene: Tacr3 / 24808
• RGDID: 3810
• Length: 452
• Species: Rattus norvegicus
• Alignment Length: 463
• Identity: 127/463 - (27%)
• Similarity: 213/463 - (46%)
• Gaps: 81/463 - (17%)

  Fly   111 TTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAA 175
            |..|..|.....:|.:.|..|...:.:   ||.            :|:.|.| ||||...|...|
  Rat    11 TDGTVEVGTHTGNLSSALGVTEWLALQ---AGN------------FSSALGL-PATTQAPSQVRA 59

  Fly   176 --TKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPR 238
              |..:                 ..|.:|.:|     :.:||.:|..|.:.||..||.::|...|
  Rat    60 NLTNQF-----------------VQPSWRIAL-----WSLAYGLVVAVAVFGNLIVIWIILAHKR 102

  Fly   239 MRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVS 303
            ||||||||:||||.:|..|..|......|..:...|..|...|:|..:....:|.||:||:.|::
  Rat   103 MRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA 167

  Fly   304 LDRFIAIWWPLKQMTKRRARIMIIG-IWVIALVTTIPWLLF--FDLVPAEEVFSDALVSAYSQPQ 365
            :||::||..|||......|..::|| ||::|.:...|..|:  ..::|.               :
  Rat   168 VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPG---------------R 217

  Fly   366 FLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKS 430
            .||...||.|...:..:.:..::..|..|:.::.:.|.::.|.:....|||::.|...:  |.|:
  Rat   218 TLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHE--QLKA 280

  Fly   431 KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILY 495
            |.||:||::.||:.|.:.|||.:|.|........:::  ::.:::|...:.||..|::..|||:|
  Rat   281 KRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNR--WKYIQQVYLASFWLAMSSTMYNPIIY 343

  Fly   496 -SVNKKYRRGFAAIIKSRSCCG--RLRYYDNVAIASSTT---STRKSSHYHQNSSRKSPSSKGNA 554
             .:||::|.||....:   .|.  ::..||.:.:  .||   .||:||.|        ..|:..:
  Rat   344 CCLNKRFRAGFKRAFR---WCPFIQVSSYDELEL--KTTRFHPTRQSSLY--------TVSRMES 395

  Fly   555 VSYIYEHN 562
            |:.:::.|
  Rat   396 VTVLFDPN 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	91/299 (30%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	6/18 (33%)
		TM helix 5	379..404	CDD:320124	3/24 (13%)
		TM helix 6	429..459	CDD:320124	14/29 (48%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
Tacr3	NP_058749.1	7tmA_NKR_NK3R	73..354	CDD:320669	92/304 (30%)
		TM helix 1	74..100	CDD:320669	10/30 (33%)
		TM helix 2	107..133	CDD:320669	12/25 (48%)
		TM helix 3	145..175	CDD:320669	11/29 (38%)
		TM helix 4	186..207	CDD:320669	7/20 (35%)
		TM helix 5	231..260	CDD:320669	3/28 (11%)
		TM helix 6	279..309	CDD:320669	14/29 (48%)
		TM helix 7	322..347	CDD:320669	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..452		1/4 (25%)