Protein Alignment SIFaR and Hcrtr1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_945197.2
• Gene: Hcrtr1 / 230777
• MGIID: 2385650
• Length: 416
• Species: Mus musculus
• Alignment Length: 436
• Identity: 130/436 - (29%)
• Similarity: 201/436 - (46%)
• Gaps: 90/436 - (20%)

  Fly   162 LSPATTSLISAAAATKS---------YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIV 217
            :.|:.|........|.|         |.|..||:...|          |.:......|...||:.
Mouse     1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRD----------YLYPKQYEWVLIAAYVA 55

  Fly   218 VFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCK 282
            |||:.|:||:.|...|.|...||||||||||||::||:||...||||:|:.:|...|:.|..:||
Mouse    56 VFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGQALCK 120

  Fly   283 FVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFF-- 344
            .:||:|.|||:.:|.:|..::|||:.||..||. :.|.||||..|:|||.::|...:|.....
Mouse   121 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMEC 185

  Fly   345 -----DLVPAEEVFSDALVSAYSQPQFLCQEVWP----PGTDGNLYFLLANLVACYLLPMSLITL 400
                 :|.....:||            :|.|.|.    |....:.:|::.     ||.|:.|:.:
Mouse   186 SSVLPELANRTRLFS------------VCDEHWADELYPKIYHSCFFIVT-----YLAPLGLMAM 233

  Fly   401 CYVLIWIKVSTRSIPG-------------ESKDAQMDRM----------------QQKSKVKVIK 436
            .|..|:.|:..|.|||             |..:||...:                |.:::.|..|
Mouse   234 AYFQIFRKLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAK 298

  Fly   437 MLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VN 498
            ||:.|:::|.|.:||:.|  :..|: ||......:.|.:......:.||..:||..|||:|: ::
Mouse   299 MLMVVLLVFALCYLPISVLNVLKRV-FGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362

  Fly   499 KKYRRGFAAIIKSRSCC------GRLRYYDNVAIASSTTSTRKSSH 538
            .|:|..|.|..   |||      |....:.::::.|..:.::.|.|
Mouse   363 GKFREQFKAAF---SCCLPGLGPGSSARHKSLSLQSRCSVSKVSEH 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	111/339 (33%)
		TM helix 1	210..236	CDD:320124	11/25 (44%)
		TM helix 2	243..269	CDD:320124	17/25 (68%)
		TM helix 3	281..311	CDD:320124	14/29 (48%)
		TM helix 4	322..340	CDD:320124	7/17 (41%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	10/31 (32%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
Hcrtr1	NP_945197.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/20 (20%)
		Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613	26..41		6/24 (25%)
		7tmA_OXR	47..369	CDD:320336	111/339 (33%)
		TM helix 1	48..74	CDD:320336	11/25 (44%)
		TM helix 2	81..107	CDD:320336	17/25 (68%)
		TM helix 3	119..149	CDD:320336	14/29 (48%)
		TM helix 4	160..181	CDD:320336	9/20 (45%)
		TM helix 5	212..241	CDD:320336	8/33 (24%)
		TM helix 6	291..321	CDD:320336	10/29 (34%)
		TM helix 7	337..362	CDD:320336	8/24 (33%)