DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIFaR and Hcrtr1

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001156499.1	Gene:	Hcrtr1 / 230777	MGIID:	2385650	Length:	416	Species:	Mus musculus

Alignment Length:	436	Identity:	130/436 - (29%)
Similarity:	201/436 - (46%)	Gaps:	90/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LSPATTSLISAAAATKS---------YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIV 217
            :.|:.|........|.|         |.|..||:...|          |.:......|...||:.
Mouse     1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRD----------YLYPKQYEWVLIAAYVA 55

  Fly   218 VFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCK 282
            |||:.|:||:.|...|.|...||||||||||||::||:||...||||:|:.:|...|:.|..:||
Mouse    56 VFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGQALCK 120

  Fly   283 FVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFF-- 344
            .:||:|.|||:.:|.:|..::|||:.||..||. :.|.||||..|:|||.::|...:|.....
Mouse   121 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMEC 185

  Fly   345 -----DLVPAEEVFSDALVSAYSQPQFLCQEVWP----PGTDGNLYFLLANLVACYLLPMSLITL 400
                 :|.....:||            :|.|.|.    |....:.:|::.     ||.|:.|:.:
Mouse   186 SSVLPELANRTRLFS------------VCDEHWADELYPKIYHSCFFIVT-----YLAPLGLMAM 233

  Fly   401 CYVLIWIKVSTRSIPG-------------ESKDAQMDRM----------------QQKSKVKVIK 436
            .|..|:.|:..|.|||             |..:||...:                |.:::.|..|
Mouse   234 AYFQIFRKLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAK 298

  Fly   437 MLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VN 498
            ||:.|:::|.|.:||:.|  :..|: ||......:.|.:......:.||..:||..|||:|: ::
Mouse   299 MLMVVLLVFALCYLPISVLNVLKRV-FGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362

  Fly   499 KKYRRGFAAIIKSRSCC------GRLRYYDNVAIASSTTSTRKSSH 538
            .|:|..|.|..   |||      |....:.::::.|..:.::.|.|
Mouse   363 GKFREQFKAAF---SCCLPGLGPGSSARHKSLSLQSRCSVSKVSEH 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	89/267 (33%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	101/312 (32%)
Hcrtr1	NP_001156499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		4/20 (20%)
		Required for response to orexin-A. /evidence=ECO:0000250\|UniProtKB:O43613	26..41		6/24 (25%)
		7tmA_OXR	47..369	CDD:320336	111/339 (33%)
		TM helix 1	49..73	CDD:320336	10/23 (43%)
		TM helix 2	82..104	CDD:320336	15/21 (71%)
		TM helix 3	120..142	CDD:320336	9/21 (43%)
		TM helix 4	163..179	CDD:320336	5/15 (33%)
		TM helix 5	213..236	CDD:320336	5/27 (19%)
		TM helix 6	297..319	CDD:320336	9/21 (43%)
		TM helix 7	337..362	CDD:320336	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8802
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840