Protein Alignment SIFaR and Qrfpr

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_937835.1
• Gene: Qrfpr / 229214
• MGIID: 2677633
• Length: 433
• Species: Mus musculus
• Alignment Length: 474
• Identity: 129/474 - (27%)
• Similarity: 219/474 - (46%)
• Gaps: 94/474 - (19%)

  Fly   195 FGFDPL-YRHSL--AMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADIL 256
            :|..|| |...|  ...:.:.:|..::|.:.|.|||.||.||.|:..||||||.||.:||::|:|
Mouse    29 YGLRPLVYTPELPARAKLAFALAGALIFALALFGNSLVIYVVTRSKAMRTVTNIFICSLALSDLL 93

  Fly   257 VIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK---QMT 318
            :..||:|.|::.||...|:.|..:||.||::|..:|...:.::..::::|...:..|.|   |.|
Mouse    94 IAFFCIPVTMLQNISDKWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLIHPFKMKWQYT 158

  Fly   319 KRRARIMIIGIWVIALVTTIP-WLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLY- 381
            .|||..::..:|:.|::...| |     .|...|:..|.|   |.:....|.|.|.......:|
Mouse   159 TRRAFTILGVVWLAAIIVGSPMW-----HVQRLEIKYDFL---YEKEHVCCLEEWASPMHQRIYT 215

  Fly   382 -FLLANLVACYLLPMSLITLCYVLI----WIK------VSTRSIPGESKDAQMDRMQQKSKVKVI 435
             |:   ||..:|||:.::.:.|..|    |||      .:.::|.|:    :|.::.:|.| :.:
Mouse   216 TFI---LVILFLLPLVVMLVLYSKIGYELWIKKRVGDSSALQTIHGK----EMSKIARKKK-RAV 272

  Fly   436 KMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNK 499
            .|:|.||.||...|.|.:|:...:::.:...:.:...:|.|..|||.:|..||..||.:|: :|:
Mouse   273 VMMVTVVALFAACWAPFHVVHMMVEYSNFEKEYDDVTIKMVFAVAQTIGFFNSICNPFVYAFMNE 337

  Fly   500 KYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSK-GNA-VSYIYEHN 562
            .:::.|.:.:     |        ..|...|.               ||..| ||: :|
Mouse   338 NFKKNFLSAV-----C--------YCIVRETF---------------SPGQKPGNSGIS------ 368

  Fly   563 SLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQD 627
                   |:::.:.||:......::.|         ...|||: :...||:|.  |.|..|.:|.
Mouse   369 -------MMQKRAKLSRSQRPVAEAKG---------DLFSDAN-VDVKLCEQP--GEKRQLKRQL 414

  Fly   628 SIVSYMEARRS---AGHGL 643
            :..|...:..|   :||.|
Mouse   415 AFFSSELSENSTFGSGHEL 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	95/312 (30%)
		TM helix 1	210..236	CDD:320124	10/25 (40%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	7/29 (24%)
		TM helix 4	322..340	CDD:320124	4/18 (22%)
		TM helix 5	379..404	CDD:320124	8/26 (31%)
		TM helix 6	429..459	CDD:320124	11/29 (38%)
		TM helix 7	474..498	CDD:320124	11/24 (46%)
Qrfpr	NP_937835.1	7tmA_QRFPR	46..343	CDD:320333	95/312 (30%)
		TM helix 1	47..73	CDD:320333	10/25 (40%)
		TM helix 2	80..106	CDD:320333	12/25 (48%)
		TM helix 3	118..148	CDD:320333	7/29 (24%)
		TM helix 4	161..182	CDD:320333	6/25 (24%)
		TM helix 5	211..236	CDD:320333	8/27 (30%)
		TM helix 6	266..296	CDD:320333	11/30 (37%)
		TM helix 7	311..336	CDD:320333	11/24 (46%)