Protein Alignment SIFaR and Tacr1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_033339.2
• Gene: Tacr1 / 21336
• MGIID: 98475
• Length: 407
• Species: Mus musculus
• Alignment Length: 397
• Identity: 106/397 - (26%)
• Similarity: 190/397 - (47%)
• Gaps: 46/397 - (11%)

  Fly   209 MVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVP 273
            :::..||.|:.:..::||..||.::|...|||||||||:||||.|:..:..|.........:...
Mouse    33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV 97

  Fly   274 WMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTT 337
            |..|...|||..:....::.||:||:.||:.||::||..||: :::....:::|..|||:||:..
Mouse    98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLA 162

  Fly   338 IP--WLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP--PGTDGNLYFLLANLVACYLLPMSLI 398
            .|  :....:.:|:..|               |...||  |.......:.:...|..|.||:.:|
Mouse   163 FPQGYYSTTETMPSRVV---------------CMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVI 212

  Fly   399 TLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGS 463
            ...|.::.|.:....|||:|.|...:  |..:|.||:||::.||..|.:.|||.::.|.......
Mouse   213 GYAYTVVGITLWASEIPGDSSDRYHE--QVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP 275

  Fly   464 DISQEEFEILKKVMPVAQWLGSSNSCINPILY-SVNKKYRRGFAAIIKSRSCCGRLRY--YDNVA 525
            |:..::|  :::|...:.||..|::..|||:| .:|.::|.||....:   ||..:..  |:.:.
Mouse   276 DLYLKKF--IQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFR---CCPFISAGDYEGLE 335

  Fly   526 IASSTTSTRKSSHY---------------HQNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDS 575
            :.|:.....:||.|               |::...:.|.:..:::. :..:.|.|.::..:.:.|
Mouse   336 MKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLD-LTSNGSSRSNSKTMTESS 399

  Fly   576 NLSQQML 582
            :....||
Mouse   400 SFYSNML 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	90/301 (30%)
		TM helix 1	210..236	CDD:320124	8/25 (32%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	12/29 (41%)
		TM helix 4	322..340	CDD:320124	7/19 (37%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	12/29 (41%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
Tacr1	NP_033339.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		7tm_GPCRs	33..316	CDD:475119	90/301 (30%)
		TM helix 1	35..59	CDD:320668	7/23 (30%)
		TM helix 2	68..90	CDD:320668	9/21 (43%)
		TM helix 3	106..128	CDD:320668	8/21 (38%)
		TM helix 4	149..165	CDD:320668	6/15 (40%)
		TM helix 5	194..217	CDD:320668	5/22 (23%)
		TM helix 6	247..269	CDD:320668	8/21 (38%)
		TM helix 7	284..309	CDD:320668	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..407		7/46 (15%)