Protein Alignment SIFaR and tkr-1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 400
• Identity: 106/400 - (26%)
• Similarity: 179/400 - (44%)
• Gaps: 72/400 - (18%)

  Fly   188 QLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAI 252
            :|:|.  |...|..|.|||..:...:|::::....:||||.|:.::.:...|....|||:.|:|.
 Worm    25 ELEGI--FFCAPSSRESLATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAF 87

  Fly   253 ADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ- 316
            ||:|:.:|.:..:...|::..|..|.| |....:........||.|::|:|.||..|:..||::
 Worm    88 ADLLIALFNVGTSWTYNLYYDWWYGDL-CTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKR 151

  Fly   317 -MTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFS----DALVSAYSQPQFLCQEVWPPGT 376
             ::::|:.|.|:.|||::.||.:|:.:      |..|.|    |.:.|..|:.......|
 Worm   152 PLSRKRSVIAILIIWVVSTVTALPFAI------AASVNSLYTYDVVTSTVSKAHVCSAPV----- 205

  Fly   377 DGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAV 441
              |.:|........|.||  :|.|......|.|:.|: ..|:.|:.:.....::|.|.:|||..:
 Worm   206 --NTFFEKVLFGIQYALP--IIILGSTFTRIAVAFRA-TNEATDSSLKNNHTRAKSKAVKMLFLM 265

  Fly   442 VILFVLSWLP--LYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRR 503
            |:.||:.|||  :|..||..:| .|.::.::..|     :..|:..|:...|||:|. .|:::|.
 Worm   266 VVAFVVCWLPYHIYHAFALEEF-FDAARGKYAYL-----LIYWIAMSSCAYNPIIYCFANERFRI 324

  Fly   504 GFAAII---------------------KSRSCC-----GRLR------------YYDNVAIASST 530
            ||..:.                     |.||..     ||:.            ..|.|.:..|.
 Worm   325 GFRYVFRWIPVIDCKKEQYEYSQLFPDKMRSMAISLQKGRVNSSCLDKKVKENSSQDLVCVMHSE 389

  Fly   531 TSTRKSSHYH 540
            .:|:|.|..|
 Worm   390 KNTKKYSKVH 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	84/304 (28%)
		TM helix 1	210..236	CDD:320124	6/25 (24%)
		TM helix 2	243..269	CDD:320124	9/25 (36%)
		TM helix 3	281..311	CDD:320124	9/29 (31%)
		TM helix 4	322..340	CDD:320124	7/17 (41%)
		TM helix 5	379..404	CDD:320124	7/24 (29%)
		TM helix 6	429..459	CDD:320124	14/31 (45%)
		TM helix 7	474..498	CDD:320124	6/24 (25%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	84/304 (28%)
		TM helix 1	46..70	CDD:320512	6/23 (26%)
		TM helix 2	79..101	CDD:320512	9/21 (43%)
		TM helix 3	116..138	CDD:320512	4/21 (19%)
		TM helix 4	160..176	CDD:320512	7/15 (47%)
		TM helix 5	207..230	CDD:320512	6/24 (25%)
		TM helix 6	259..281	CDD:320512	10/21 (48%)
		TM helix 7	294..319	CDD:320512	7/29 (24%)