Protein Alignment SIFaR and npr-22

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001023541.1
• Gene: npr-22 / 190424
• WormBaseID: WBGene00022004
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 452
• Identity: 117/452 - (25%)
• Similarity: 205/452 - (45%)
• Gaps: 88/452 - (19%)

  Fly   122 SSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRW 186
            ||||:.:  |||||                     ..::...|.||.    ..|.:..|.
 Worm     9 SSLLSRI--TTTAS---------------------EIMMRNEPTTTE----NPAVQEMNH----- 41

  Fly   187 EQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLA 251
                         :|..:.:|.|:..:.|.::.:..:.||..||.|::...|:||.||..|:|||
 Worm    42 -------------IYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLA 93

  Fly   252 IADILVIVFCLPATLIGNIFVP---WMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWW- 312
            :||:|:.|||:|.:....:...   |:.|.:||..:.::|.::|..|.::|:.:|.||::||.:
 Worm    94 VADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFL 158

  Fly   313 --PLKQMTKRRARIMIIGIWVIALVTTIPWLL---FFDLVPAEEVFSDALVSAYSQPQFLCQEVW 372
              |..::|:|||..::...|:.:::..:|.|.   ||:       ..|.|.:        |.|.|
 Worm   159 LTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFE-------DQDGLPN--------CGENW 208

  Fly   373 PP-GTDG----NLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIP----GESKDAQMDRMQQ 428
            .. |..|    .:|..:. |:..|::|.:::.:.|..|.||:....:|    |.:|...:||  .
 Worm   209 TYFGDSGEQVRKVYSSMV-LILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDR--H 270

  Fly   429 KSKVKVIKMLVAVVILFVLSWLPLYVIFARI-KFGSDISQEEFEILKKVMPVAQWLGSSNSCINP 492
            :|..|::.|::.:..||.|.||||.::...| :|..||:  .:..:..:...|..|..|:|.:||
 Worm   271 ESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDIN--SWGYILYLWWFAHGLAMSHSMVNP 333

  Fly   493 ILYSV-NKKYRRGFAAIIKSRSCC---GRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSS 550
            |:|.: |.::|.||.........|   ..||...:....|....:|.|...:..||.:.|::
 Worm   334 IIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPAT 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	90/315 (29%)
		TM helix 1	210..236	CDD:320124	6/25 (24%)
		TM helix 2	243..269	CDD:320124	13/25 (52%)
		TM helix 3	281..311	CDD:320124	9/29 (31%)
		TM helix 4	322..340	CDD:320124	2/17 (12%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	10/29 (34%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	90/315 (29%)
		TM helix 1	52..78	CDD:320514	6/25 (24%)
		TM helix 2	85..110	CDD:320514	13/24 (54%)
		TM helix 3	126..156	CDD:320514	9/29 (31%)
		TM helix 4	169..190	CDD:320514	4/20 (20%)
		TM helix 5	219..248	CDD:320514	6/29 (21%)
		TM helix 6	271..301	CDD:320514	10/29 (34%)
		TM helix 7	315..340	CDD:320514	8/24 (33%)