Protein Alignment SIFaR and npr-5

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001024265.1
• Gene: npr-5 / 190386
• WormBaseID: WBGene00021983
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 134/498 - (26%)
• Similarity: 214/498 - (42%)
• Gaps: 120/498 - (24%)

  Fly   150 ATSSTYYSNLLNLSPATT-SLISAAAATKSYNDSALRWEQL-------DGSVDFGFDPLYRHSLA 206
            ||.||       :|..|| |.||....:.|.|.|.::..:.       |.:|||     |..|
 Worm     6 ATIST-------ISTTTTPSTISNVITSHSNNGSCIQIAEAIAAQGIDDITVDF-----YIRS-- 56

  Fly   207 MSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIF 271
               ::...|..:|::|:.||..|:..|.|..|:::..|.|::||...|::::...:|.|....:.
 Worm    57 ---IFTFLYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMT 118

  Fly   272 VPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ-MTKRRARIMIIGIWVIALV 335
            ..|..|.:||..||.....||..:.:||.|:|||:|:.|..|.|| ::.|:|..:...||:::.:
 Worm   119 KDWAFGSVMCHLVPLSNSCSVFVTSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTL 183

  Fly   336 TTIPWLLFFDLVPAEEVFSDALVSAYSQP------QFLCQEV-WPPGTDGNLYFLLANLVACYLL 393
            ..:|:|:.|:.|..         |.|.||      ...|.|. |.......:|.....|:. :::
 Worm   184 INLPYLMSFEHVDG---------SFYVQPGETPYCGHFCDEANWQSENSRKIYGTTVMLLQ-FVV 238

  Fly   394 PMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKS-----KVKVIKMLVAVVILFVLSWLPLY 453
            ||::||.||..|..|||...|...::..|....:|:|     |.||..:|:|:|:.|:..||||.
 Worm   239 PMAVITYCYFKILQKVSKDMIIQNAQFCQSLTQKQRSDATSRKKKVNYILIAMVVTFIGCWLPLT 303

  Fly   454 VIFARIKFGSDISQEEFEILKK------------VMPVAQWLGSSNSCINPILY--SVNKKYRRG 504
            :    :....|..:|. |.||:            .|.:..|        ||:|:  ...|:.|.|
 Worm   304 L----LNLVKDFKKEP-EWLKRQPFFWAINAHVIAMSLVVW--------NPLLFFWLTRKQKRSG 355

  Fly   505 FAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNM 569
            .:.|:.|            ..|.||..| |.|     ||.|:|               :.||:|:
 Worm   356 LSKILNS------------TEIVSSFAS-RVS-----NSIRRS---------------TFRRNNI 387

  Fly   570 MLKQDSNLSQQMLLKQDSHG------SRQFLIKQESSCSDASG 606
                |....:|::|  |..|      ||..||:.:...:.::|
 Worm   388 ----DRVRKKQVVL--DCEGSSYTTSSRPLLIRTDVQATLSNG 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	89/322 (28%)
		TM helix 1	210..236	CDD:320124	7/25 (28%)
		TM helix 2	243..269	CDD:320124	7/25 (28%)
		TM helix 3	281..311	CDD:320124	12/29 (41%)
		TM helix 4	322..340	CDD:320124	3/17 (18%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	12/34 (35%)
		TM helix 7	474..498	CDD:320124	6/37 (16%)
npr-5	NP_001024265.1	7tmA_NPYR-like	56..347	CDD:320331	88/318 (28%)
		TM helix 1	57..83	CDD:320331	7/25 (28%)
		TM helix 2	90..115	CDD:320331	7/24 (29%)
		TM helix 3	128..158	CDD:320331	12/29 (41%)
		TM helix 4	169..190	CDD:320331	4/20 (20%)
		TM helix 5	224..253	CDD:320331	9/29 (31%)
		TM helix 6	279..309	CDD:320331	11/33 (33%)
		TM helix 7	323..347	CDD:320331	5/31 (16%)