Protein Alignment SIFaR and npr-14

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001379223.1
• Gene: npr-14 / 189211
• WormBaseID: WBGene00012275
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 403
• Identity: 109/403 - (27%)
• Similarity: 201/403 - (49%)
• Gaps: 65/403 - (16%)

  Fly   170 ISAAAATKSYNDSALRWEQLDGSVDFG---FDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIA 231
            :::.::.:.|:.|.:...|::...::.   .:.|:.:::....||.:|.::|  :|:|||:.|:.
 Worm     7 VTSGSSEEDYDTSEIIGLQVNTHEEYEDIIAEALWPNAVEQWFVYILASMMV--IGVIGNTLVVV 69

  Fly   232 VVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASV 296
            ||.....||...|..::||||||:|:::||||.|::.::...:....:.||.|.::...||..|:
 Worm    70 VVATNKSMRNALNLVLMNLAIADLLILLFCLPLTVVNDVTKTFWFSAVFCKSVNFVNNTSVYVSI 134

  Fly   297 YSLIAVSLDRFIAIWWPLKQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAY 361
            .||:.::.:|:.||.:|||.... |.|.:|.|||.||:..:.|          |.|......:.:
 Worm   135 MSLVFITCERWRAITYPLKSPFV-RTRSVIGGIWFIAMFLSSP----------EPVTLHLAGAPF 188

  Fly   362 SQPQFL------CQEVWPPGTDGNLYFLLANLVACYLLPMSLIT-LCYVLI--------WIKVST 411
            .:|.|.      |:|.|......| |.||..:.: ::||:.:|: ||..::        ::.|:.
 Worm   189 VRPNFTTKWGTRCKESWSEEFQKN-YQLLQTIFS-FVLPLLVISILCLHMVRTLHFSANYLTVAN 251

  Fly   412 RSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKF---GSDISQEEFEIL 473
            |.|              ..:.|.::||.|||.||.:|.||:::....:.:   .:|:|.....:
 Worm   252 RQI--------------SIRKKAVRMLCAVVFLFSMSNLPVHLYNIALNYDLLSTDVSTNTIAV- 301

  Fly   474 KKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSS 537
            :|::|  :....|:||:|||||| ::.::|..|..::    ||.|    |.   .||....||.:
 Worm   302 RKLLP--RVFSYSSSCLNPILYSFLSGRFREEFGRVV----CCLR----DE---KSSREFRRKQA 353

  Fly   538 HYHQNSSRKSPSS 550
            ..:.:|.|...:|
 Worm   354 SLYASSQRVRTNS 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	93/314 (30%)
		TM helix 1	210..236	CDD:320124	11/25 (44%)
		TM helix 2	243..269	CDD:320124	13/25 (52%)
		TM helix 3	281..311	CDD:320124	10/29 (34%)
		TM helix 4	322..340	CDD:320124	7/17 (41%)
		TM helix 5	379..404	CDD:320124	9/25 (36%)
		TM helix 6	429..459	CDD:320124	11/29 (38%)
		TM helix 7	474..498	CDD:320124	11/24 (46%)
npr-14	NP_001379223.1	7tmA_CCKR-like	48..332	CDD:320124	93/315 (30%)
		TM helix 1	48..74	CDD:320124	11/27 (41%)
		TM helix 2	81..107	CDD:320124	13/25 (52%)
		TM helix 3	119..149	CDD:320124	10/29 (34%)
		TM helix 4	159..177	CDD:320124	8/27 (30%)
		TM helix 5	210..235	CDD:320124	9/26 (35%)
		TM helix 6	255..285	CDD:320124	11/29 (38%)
		TM helix 7	300..325	CDD:320124	11/27 (41%)