DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and Oprm1

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001291884.1 Gene:Oprm1 / 18390 MGIID:97441 Length:474 Species:Mus musculus


Alignment Length:525 Identity:132/525 - (25%)
Similarity:236/525 - (44%) Gaps:118/525 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 TASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGF 197
            :::..|:::..|..:|.|:.|....:.||||....:........::         .|.||     
Mouse     3 SSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRT---------GLGGS----- 53

  Fly   198 DPLYRHSL-----AMSMVYCVA----YIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIA 253
                 |||     :.|||..:.    |.:|.:|||.||..|:.|::|..:|:|.||.:|.|||:|
Mouse    54 -----HSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALA 113

  Fly   254 DILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM- 317
            |.|. ...||...:..:...|..|.::||.|..|...::..|:::|..:|:||:||:..|:|.: 
Mouse   114 DALA-TSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALD 177

  Fly   318 --TKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNL 380
              |.|.|:|:.:..|:::....:| ::|.......:...|..:: :|.|.:    .|.     ||
Mouse   178 FRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLT-FSHPTW----YWE-----NL 231

  Fly   381 YFLLANLVACYLLPMSLITLCYVLIWIKV-STRSIPG-ESKDAQMDRMQQKSKVKVIKMLVAVVI 443
            ..:...:.| :::|:.:||:||.|:.::: |.|.:.| :.||..:.|        :.:|::.||.
Mouse   232 LKICVFIFA-FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRR--------ITRMVLVVVA 287

  Fly   444 LFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAA 507
            :|::.|.|:: |:..||....|.:..|:.:.....:|  ||.:|||:||:||: :::.::|.|  
Mouse   288 VFIVCWTPIH-IYVIIKALITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF-- 347

  Fly   508 IIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGN------------AVSYIY- 559
                |..|         ...|||...:.|:...|| :|:.||:...            :|:.|: 
Mouse   348 ----REFC---------IPTSSTIEQQNSARIRQN-TREHPSTANTVDRTNHQPTLAVSVAQIFT 398

  Fly   560 --------------------------EHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFL---- 594
                                      :..|||::....|:..| .|.:|....|.|.|..|    
Mouse   399 GYPSPTHVEKPCKSCMDSVDCYNRKQQTGSLRKNKKKKKRRKN-KQNILEAGISRGMRNLLPDDG 462

  Fly   595 IKQES 599
            .:|||
Mouse   463 PRQES 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 88/305 (29%)
TM helix 1 210..236 CDD:320124 10/29 (34%)
TM helix 2 243..269 CDD:320124 11/25 (44%)
TM helix 3 281..311 CDD:320124 11/29 (38%)
TM helix 4 322..340 CDD:320124 3/17 (18%)
TM helix 5 379..404 CDD:320124 8/24 (33%)
TM helix 6 429..459 CDD:320124 7/29 (24%)
TM helix 7 474..498 CDD:320124 10/24 (42%)
Oprm1NP_001291884.1 7tmA_Mu_opioid_R 69..347 CDD:320218 86/301 (29%)
TM helix 1 70..96 CDD:320218 9/25 (36%)
TM helix 2 103..129 CDD:320218 11/26 (42%)
TM helix 3 140..170 CDD:320218 11/29 (38%)
TM helix 4 182..204 CDD:320218 5/22 (23%)
TM helix 5 229..258 CDD:320218 9/34 (26%)
TM helix 6 273..303 CDD:320218 8/38 (21%)
TM helix 7 315..340 CDD:320218 10/26 (38%)
NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000269|PubMed:26245379 332..336 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..383 6/21 (29%)

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