Protein Alignment SIFaR and npr-35

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001023088.2
• Gene: npr-35 / 183681
• WormBaseID: WBGene00016842
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 389
• Identity: 125/389 - (32%)
• Similarity: 202/389 - (51%)
• Gaps: 67/389 - (17%)

  Fly   199 PLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLP 263
            ||.|||..::::|.|||..||..|::||:||:..|.....:...|:|.|::||:||:.::..|||
 Worm    23 PLLRHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLP 87

  Fly   264 ATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMT---KRRARIM 325
            .|||.:||..|:.|...|:...:....:..||||:|:||:.||::||...||..|   :...:.:
 Worm    88 TTLINSIFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYV 152

  Fly   326 IIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPG----------TDGNL 380
            |..:|::|.:..||....:||:                       ||..|          ||..|
 Worm   153 IFAVWLVAAIFGIPNWYNYDLI-----------------------VWQEGSYGYRLCTSQTDQKL 194

  Fly   381 YFLLANLVACYLLPMSLITLCYVLIWIKVST-RSIPGESKDAQMDRMQQKSKVKVIKMLVAVVIL 444
            |||..||:..:::|..||:..|..|:|.||| ||:..::: |:.||:    |::|..|::.|:|:
 Worm   195 YFLFVNLLLAFIVPFGLISGLYTRIFITVSTHRSLAVDAR-AREDRV----KLRVATMMLTVIIV 254

  Fly   445 FVLSWLPLYVIFARIKFGSDISQEEFEILKK-VMPVAQWLGSSNSCINPILY-SVNKKYRRGFAA 507
            |...|||||.||....|.:|...:.|:|... :.|:.||:...:|.:|||:| :.:.||||.|.:
 Worm   255 FACCWLPLYCIFTYFFFFADQRSDLFQITSMLIRPIFQWMSLLSSSLNPIIYIAYSHKYRRAFKS 319

  Fly   508 II----KSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKS-------PSSKGNAVSYIYE 560
            |:    |:|        |:.|    .:|..|:.|...::::..|       |::.|.|.|.:.|
 Worm   320 ILLMPCKTR--------YERV----RSTILRRHSRGFKSTATISMSNFGTEPTNLGGASSLLIE 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	105/311 (34%)
		TM helix 1	210..236	CDD:320124	12/25 (48%)
		TM helix 2	243..269	CDD:320124	13/25 (52%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	4/17 (24%)
		TM helix 5	379..404	CDD:320124	10/24 (42%)
		TM helix 6	429..459	CDD:320124	13/29 (45%)
		TM helix 7	474..498	CDD:320124	8/25 (32%)
npr-35	NP_001023088.2	7tm_GPCRs	33..317	CDD:475119	105/311 (34%)
		TM helix 1	35..59	CDD:410628	12/23 (52%)
		TM helix 2	68..90	CDD:410628	9/21 (43%)
		TM helix 3	106..128	CDD:410628	7/21 (33%)
		TM helix 4	151..167	CDD:410628	4/15 (27%)
		TM helix 5	194..217	CDD:410628	9/22 (41%)
		TM helix 6	245..267	CDD:410628	10/21 (48%)
		TM helix 7	285..310	CDD:410628	8/24 (33%)