DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and npr-35

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001023088.1	Gene:	npr-35 / 183681	WormBaseID:	WBGene00016842	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	125/389 - (32%)
Similarity:	202/389 - (51%)	Gaps:	67/389 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 PLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLP 263
            ||.|||..::::|.|||..||..|::||:||:..|.....:...|:|.|::||:||:.::..|||
Worm    20 PLLRHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLP 84

  Fly   264 ATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMT---KRRARIM 325
            .|||.:||..|:.|...|:...:....:..||||:|:||:.||::||...||..|   :...:.:
Worm    85 TTLINSIFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYV 149

  Fly   326 IIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPG----------TDGNL 380
            |..:|::|.:..||....:||:                       ||..|          ||..|
Worm   150 IFAVWLVAAIFGIPNWYNYDLI-----------------------VWQEGSYGYRLCTSQTDQKL 191

  Fly   381 YFLLANLVACYLLPMSLITLCYVLIWIKVST-RSIPGESKDAQMDRMQQKSKVKVIKMLVAVVIL 444
            |||..||:..:::|..||:..|..|:|.||| ||:..::: |:.||:    |::|..|::.|:|:
Worm   192 YFLFVNLLLAFIVPFGLISGLYTRIFITVSTHRSLAVDAR-AREDRV----KLRVATMMLTVIIV 251

  Fly   445 FVLSWLPLYVIFARIKFGSDISQEEFEILKK-VMPVAQWLGSSNSCINPILY-SVNKKYRRGFAA 507
            |...|||||.||....|.:|...:.|:|... :.|:.||:...:|.:|||:| :.:.||||.|.:
Worm   252 FACCWLPLYCIFTYFFFFADQRSDLFQITSMLIRPIFQWMSLLSSSLNPIIYIAYSHKYRRAFKS 316

  Fly   508 II----KSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKS-------PSSKGNAVSYIYE 560
            |:    |:|        |:.|    .:|..|:.|...::::..|       |::.|.|.|.:.|
Worm   317 ILLMPCKTR--------YERV----RSTILRRHSRGFKSTATISMSNFGTEPTNLGGASSLLIE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	76/240 (32%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	93/284 (33%)
npr-35	NP_001023088.1	7tm_GPCRs	30..314	CDD:391938	105/311 (34%)
		TM helix 1	31..57	CDD:341315	12/25 (48%)
		TM helix 2	64..90	CDD:341315	13/25 (52%)
		TM helix 3	102..132	CDD:341315	11/29 (38%)
		TM helix 4	146..164	CDD:341315	4/17 (24%)
		TM helix 5	190..215	CDD:341315	10/24 (42%)
		TM helix 6	236..267	CDD:341315	14/34 (41%)
		TM helix 7	282..307	CDD:341315	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I2544
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0014380
OrthoInspector	1	1.000	-	-		otm14687
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910