Protein Alignment SIFaR and tkr-2

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_500930.1
• Gene: tkr-2 / 183595
• WormBaseID: WBGene00016761
• Length: 391
• Species: Caenorhabditis elegans
• Alignment Length: 363
• Identity: 96/363 - (26%)
• Similarity: 180/363 - (49%)
• Gaps: 35/363 - (9%)

  Fly   162 LSPATTSLISAAAATKSYNDSALR------WEQL--DGSVDFGFDPL-YRHSLAMSMVYCVAYIV 217
            |.|:...:....||.|..|.|.:.      ::|:  ...|.|.|:|. :.|.:...:.|.:.:.:
 Worm     6 LPPSLDEMDLRLAADKVLNGSLINCTFQSFYDQMYQTHGVYFIFEPTPFVHPIVSQIFYGILFTL 70

  Fly   218 VFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCK 282
            ...:.|:||..|:.::|...:||:||||::.|||:||..:.||....:...|.:..|..|...|:
 Worm    71 TIFLALMGNFTVMWIILYHRQMRSVTNYYLFNLAVADASISVFNTGFSWSYNYYYVWKFGSFYCR 135

  Fly   283 FVPYIQGVS-VAASVYSLIAVSLDRFIAIWWPLKQMTKRRARI-MIIGIWVIALVTTIPWLLFFD 345
             :..:.|:: :.|||:::|.:|::|:.||..|||:...||:.: :||.||.:|.:..:|..|
 Worm   136 -INNLMGITPICASVFTMIVMSIERYYAIIHPLKKRPGRRSTVTIIIMIWFMAFLFGVPAFL--- 196

  Fly   346 LVPAEEV----FSDALVSAYSQPQFLC-QEVWPPGTDGNLYFLLAN--LVACYLLPMSLITLCYV 403
               |.:|    |.|. .:.|..|  || .:.:|.|.:..|..:..|  :...|:||:.:::..|.
 Worm   197 ---ASKVDVYYFYDG-YTLYENP--LCLADNYPGGNESLLGQVYNNGLITVQYILPLCILSAAYY 255

  Fly   404 LIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQE 468
            .:.:::......|:.:.|:....::|:.:    ||..||.:|::.|.|....:..:.....|..:
 Worm   256 RVGVELRKDKTVGDVRHAKSVAAKKKASI----MLAVVVFIFMIVWFPYNAYYLTLHLVEPIGNK 316

  Fly   469 EFEILKKVMPVAQWLGSSNSCINPIL-YSVNKKYRRGF 505
            ...:.  :.....|||.|::..||:: |.:||::|.||
 Worm   317 MLSLY--IYINIYWLGMSSTVFNPVIYYFMNKRFRVGF 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	81/305 (27%)
		TM helix 1	210..236	CDD:320124	6/25 (24%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	9/30 (30%)
		TM helix 4	322..340	CDD:320124	5/18 (28%)
		TM helix 5	379..404	CDD:320124	6/26 (23%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	7/24 (29%)
tkr-2	NP_500930.1	7tmA_TACR	62..352	CDD:320512	81/305 (27%)
		TM helix 1	63..89	CDD:320512	6/25 (24%)
		TM helix 2	96..122	CDD:320512	10/25 (40%)
		TM helix 3	134..164	CDD:320512	9/30 (30%)
		TM helix 4	175..196	CDD:320512	6/20 (30%)
		TM helix 5	231..260	CDD:320512	5/28 (18%)
		TM helix 6	277..307	CDD:320512	8/33 (24%)
		TM helix 7	320..345	CDD:320512	7/26 (27%)