Protein Alignment SIFaR and npr-1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_508816.1
• Gene: npr-1 / 180752
• WormBaseID: WBGene00003807
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 116/516 - (22%)
• Similarity: 221/516 - (42%)
• Gaps: 106/516 - (20%)

  Fly   177 KSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRT 241
            :::.|..:.|:...       ||  ..|:...:.:...|:.:|.:||.||..:|.|......:.:
 Worm     4 ENFTDCQVYWKVYP-------DP--SQSIYAIVPFLTVYLFLFFLGLFGNVTLIYVTCSHKALLS 59

  Fly   242 VTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDR 306
            |.|.||:|||.:|.::.:..||.|.|.|::..|..|.|:|..:|.|||:|:....:||.|::|||
 Worm    60 VQNIFILNLAASDCMMCILSLPITPITNVYKNWYFGNLLCHLIPCIQGISIFVCTFSLGAIALDR 124

  Fly   307 FIAIWWP-LKQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQE 370
            :|.:..| ...:::|.|.:..:.:|:::.|.|:|:.....::.    :::..:..|     .|.|
 Worm   125 YILVVRPHSTPLSQRGAFLTTVLLWILSFVVTLPYAFNMQMIE----YTEERICGY-----FCTE 180

  Fly   371 VWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQM------------ 423
            .|........|.::. ::|.:::|.:::..||..|   ||..|...::|..:|
 Worm   181 KWESAKSRRAYTMIV-MLAQFVVPFAVMAFCYANI---VSVLSKRAQTKIRKMVERTSALESSCA 241

  Fly   424 -----------------DRMQQKSKVKVI-------KMLVAVVILFVLSWLPLYVIFARIKFGSD 464
                             |: |:|.|.:|:       .:||.:|:.|.::|||..||...|::...
 Worm   242 FPSHGLEQYENELNEFLDK-QEKEKQRVVLQNRRTTSILVTMVVWFGITWLPHNVISLIIEYDDT 305

  Fly   465 IS------QEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYD 522
            .|      :::::|...:......:..||:.:||:||: :|..:|:   .:||  :..|..|..|
 Worm   306 QSFFRLYGRDDYDISYLLNLFTHSIAMSNNVLNPVLYAWLNPSFRQ---LVIK--TYFGDRRKSD 365

  Fly   523 NVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDS 587
            .:.   :.||..|:...|........:..|...|    |.:|:...:     ::.|:.:....:.
 Worm   366 RII---NQTSVYKTKIVHDTKHLNGRAKIGGGGS----HEALKEREL-----NSCSENLSYHVNG 418

  Fly   588 HGSRQFLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEARRSAGHGLNDTLV 648
            |                  .|.|..:...|  :||..:...:|:  |........:|||||
 Worm   419 H------------------TRTPTPEVQLN--EVSSPEISKLVA--EPEELIEFSVNDTLV 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	84/339 (25%)
		TM helix 1	210..236	CDD:320124	8/25 (32%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	4/17 (24%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	12/36 (33%)
		TM helix 7	474..498	CDD:320124	6/24 (25%)
npr-1	NP_508816.1	7tmA_NPYR-like	27..351	CDD:320331	83/337 (25%)
		TM helix 1	28..54	CDD:320331	8/25 (32%)
		TM helix 2	61..86	CDD:320331	10/24 (42%)
		TM helix 3	99..129	CDD:320331	13/29 (45%)
		TM helix 4	140..161	CDD:320331	5/20 (25%)
		TM helix 5	188..217	CDD:320331	7/32 (22%)
		TM helix 6	270..300	CDD:320331	9/29 (31%)
		TM helix 7	321..346	CDD:320331	6/24 (25%)