Protein Alignment SIFaR and npr-34

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_497057.2
• Gene: npr-34 / 175131
• WormBaseID: WBGene00013187
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 606
• Identity: 139/606 - (22%)
• Similarity: 239/606 - (39%)
• Gaps: 147/606 - (24%)

  Fly   215 YIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWL 279
            |:.|||||.||||.||.||.|..|||.|||.|:.:|:.||:.:|.||:|...:..:...|.:|..
 Worm    79 YLTVFLVGTIGNSMVIFVVNRFKRMRNVTNIFLASLSTADLCLIWFCVPIMFMKYMSHTWSMGRF 143

  Fly   280 MCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWVIALVTTIPWL 341
            .|..|.|||..:...||.::..:|.:||:||.:|::.:   :..||:.:|:.||:.:.|..:|..
 Worm   144 ACYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRNIWFSSIGRAKKVILLIWMSSAVLAVPTA 208

  Fly   342 LFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP------PGTDGNLYFLLANLVACYLLPMSLITL 400
            :..|.        :..:|...|....|:..:|      |.|..|..:.:..|:...:.|:..:::
 Worm   209 VRMDY--------ETNLSLSGQRVHWCRRRFPAQFLGYPRTSLNKAYAMYQLLLLIIFPVLTMSI 265

  Fly   401 CY--------------------VLIWIKVSTRSIPGESKDA-----------------------Q 422
            ||                    ::.:.|.:|.::......|                       :
 Worm   266 CYARVSAIVYKSSKDRVILSQAMVAFSKAATDAVTFSGYSAIPMITTSRNLKTANTTIKSYSNHR 330

  Fly   423 MDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSN 487
            .:|:.:.:|.::::||:::|.::.:.|||..|......||........:.||.:......|....
 Worm   331 NNRVAEANKKQIVQMLISIVCMYTVCWLPTIVDELLTSFGYICRTSNTQTLKHMRMGFNALTYCQ 395

  Fly   488 SCINPILYS-VNKKYRRGFAAI---IKSR------------SCCGRLRYYDNVAIASSTTSTRKS 536
            ||||||||: :::.:|..|...   :|||            ||.           ::|..||| :
 Worm   396 SCINPILYAFISQNFRSTFKTAYSRMKSRLQGVEEMRSRMGSCS-----------SASMMSTR-N 448

  Fly   537 SHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSC 601
            .|....||..:.:..|         .|:...||    ..::||..|.:..|         |.|.|
 Worm   449 QHRIYGSSFNTLTVPG---------RSMITPNM----SRDVSQLSLCRPTS---------QMSFC 491

  Fly   602 SDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEAR-RSAGHGLNDTLVDRDSVSMDVGRRQGATP 665
            ...|    |:.             .||..::|..| ||.....:|:...|....:....:.....
 Worm   492 RPKS----PMA-------------GDSPSTFMRHRPRSPTDVSHDSGRPRSPTDLSQSTKPSRRS 539

  Fly   666 SSLLDKRQKFVKQDSVISFVDQRPEQRRHQLVKQDSVISFADQRRGLLHKQDSLMANRTGDAPTH 730
            ||:..:......|.|.|       .:.|......|:...|..:.|     ..:|.:|.:|.:
 Worm   540 SSIRPRSPTSTSQMSTI-------VRSRSPTGASDTSSLFPSRTR-----SPTLQSNTSGQS--- 589

  Fly   731 HVSILKKTDSQLSYGSSTSPR 751
                :::|..:||...:..|:
 Worm   590 ----MERTTDRLSVRDAVRPK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	89/342 (26%)
		TM helix 1	210..236	CDD:320124	14/20 (70%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	5/44 (11%)
		TM helix 6	429..459	CDD:320124	8/29 (28%)
		TM helix 7	474..498	CDD:320124	10/24 (42%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	89/342 (26%)
		TM helix 1	75..100	CDD:320132	14/20 (70%)
		TM helix 2	107..132	CDD:320132	10/24 (42%)
		TM helix 3	145..175	CDD:320132	11/29 (38%)
		TM helix 4	188..209	CDD:320132	7/20 (35%)
		TM helix 5	244..269	CDD:320132	5/24 (21%)
		TM helix 6	337..367	CDD:320132	8/29 (28%)
		TM helix 7	382..407	CDD:320132	10/24 (42%)