Protein Alignment SIFaR and Galr3

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_056553.2
• Gene: Galr3 / 14429
• MGIID: 1329003
• Length: 370
• Species: Mus musculus
• Alignment Length: 368
• Identity: 94/368 - (25%)
• Similarity: 164/368 - (44%)
• Gaps: 80/368 - (21%)

  Fly   213 VAYIVVFLVGLIGNSFVIAVVLRA-----PRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFV 272
            |.:.::||:|::||..|:||:|:.     ....:.|:.||:|||:||:..|:.|:|.........
Mouse    22 VVFALIFLLGMVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQAAIYTLD 86

  Fly   273 PWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ---MTKRRARIMIIGIWVIAL 334
            .|:.|..:||.|..:..:::.||.::|.|||:||::|:..||:.   .|.|.||..:..:|::|.
Mouse    87 AWLFGAFVCKTVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAA 151

  Fly   335 VTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFL-LANLVACYLLPMSLI 398
            :.:.|:|.::..|            .|...: ||...|   .|.....| :|...|.||||::::
Mouse   152 LFSAPYLSYYGTV------------RYGALE-LCVPAW---EDARRRALDVATFAAGYLLPVTVV 200

  Fly   399 TLCY----VLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVI---- 455
            :|.|    ..:|..|.    |..:..|:..|   ::..:..:.::.|..|:.|.|.|.:.:
Mouse   201 SLAYGRTLCFLWAAVG----PAGAAAAEARR---RATGRAGRAMLTVAALYALCWGPHHALILCF 258

  Fly   456 -FARIKFGSDISQEEFEILKKVMP-------VAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSR 512
             :.|..|.               |       .:..|..:|||:||::||:..::   |.|..:..
Mouse   259 WYGRFAFS---------------PATYACRLASHCLAYANSCLNPLVYSLASRH---FRARFRRL 305

  Fly   513 SCCGRLRYYDNVAIASSTTSTRKSSH-YHQNSSRKSPSSKGNA 554
            ..||..|:             |...| .|:...|..|:|.|.|
Mouse   306 WPCGHRRH-------------RHHHHRLHRALRRVQPASSGPA 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	81/316 (26%)
		TM helix 1	210..236	CDD:320124	10/22 (45%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	12/29 (41%)
		TM helix 4	322..340	CDD:320124	4/17 (24%)
		TM helix 5	379..404	CDD:320124	9/29 (31%)
		TM helix 6	429..459	CDD:320124	5/34 (15%)
		TM helix 7	474..498	CDD:320124	9/30 (30%)
Galr3	NP_056553.2	7tm_GPCRs	18..302	CDD:475119	83/320 (26%)
		TM helix 1	20..44	CDD:410628	9/21 (43%)
		TM helix 2	58..80	CDD:410628	10/21 (48%)
		TM helix 3	96..118	CDD:410628	7/21 (33%)
		TM helix 4	141..157	CDD:410628	2/15 (13%)
		TM helix 5	182..205	CDD:410628	8/22 (36%)
		TM helix 6	234..256	CDD:410628	5/21 (24%)
		TM helix 7	270..295	CDD:410628	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..370		4/8 (50%)