Protein Alignment SIFaR and Cckar

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_033957.1
• Gene: Cckar / 12425
• MGIID: 99478
• Length: 436
• Species: Mus musculus
• Alignment Length: 381
• Identity: 102/381 - (26%)
• Similarity: 176/381 - (46%)
• Gaps: 98/381 - (25%)

  Fly   208 SMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFV 272
            |.|..:.|..:||:.::||:.||.|::|..|||||||.|:::||::|:::.:||:|..||.|:..
Mouse    41 SAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK 105

  Fly   273 PWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ---MTKRRARIMIIGIWVIAL 334
            .::.|..:||...|..|.||:.|.::|:|:||:|:.||..||:.   .||..|..:|...|.::.
Mouse   106 DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSF 170

  Fly   335 VTTIPWLLFFDLVP-AEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLI 398
            ....|:.::.:||| .:.....|.:..:..|....|:.|..       |||..|   :|:|..::
Mouse   171 TIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQT-------FLLLIL---FLIPGVVM 225

  Fly   399 TLCYVLIWI---------------------------------------------------KVSTR 412
            .:.|.||.:                                                   |:..:
Mouse   226 VVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQ 290

  Fly   413 SIPGESKDAQMDRMQQK-------SKVKVIKMLVAVVILFVLSWLPLY----------VIFARIK 460
            .:...|...:::|::..       :|.:||:||:.:|:||.|.|:|::          |...:..
Mouse   291 QLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHL 355

  Fly   461 FGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCC 515
            .|:.||   |.:|         |..::||:|||:|. :||::|.||.|..   .||
Mouse   356 SGTPIS---FILL---------LSYTSSCVNPIIYCFMNKRFRLGFMATF---PCC 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	96/368 (26%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	3/17 (18%)
		TM helix 5	379..404	CDD:320124	7/24 (29%)
		TM helix 6	429..459	CDD:320124	12/46 (26%)
		TM helix 7	474..498	CDD:320124	7/24 (29%)
Cckar	NP_033957.1	CholecysA-Rec_N	1..47	CDD:462713	2/5 (40%)
		7tm_GPCRs	42..389	CDD:475119	96/368 (26%)
		TM helix 1	44..68	CDD:410628	8/23 (35%)
		TM helix 2	77..99	CDD:410628	8/21 (38%)
		TM helix 3	115..137	CDD:410628	8/21 (38%)
		TM helix 4	160..176	CDD:410628	2/15 (13%)
		TM helix 5	207..230	CDD:410628	7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..280		0/27 (0%)
		TM helix 6	320..342	CDD:410628	9/21 (43%)
		TM helix 7	357..382	CDD:410628	12/36 (33%)