Protein Alignment SIFaR and Kiss1r

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_444474.1
• Gene: Kiss1r / 114229
• MGIID: 2148793
• Length: 396
• Species: Mus musculus
• Alignment Length: 439
• Identity: 120/439 - (27%)
• Similarity: 191/439 - (43%)
• Gaps: 91/439 - (20%)

  Fly   150 ATSSTYYSNLLNLSPATTSLISAAAATKSYN-DSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCV 213
            ||.:|...|:...:|:..|.........|.: .||.|      .:|....||:
Mouse     2 ATEATLAPNVTWWAPSNASGCPGCGVNASDDPGSAPR------PLDAWLVPLF------------ 48

  Fly   214 AYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGW 278
             :..:.|:||:|||.||.|:.|...|:||||::|.|||..|:..::.|:|.|.:......|:||.
Mouse    49 -FATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPAWVLGD 112

  Fly   279 LMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRRARIMI---IGIWVIALVTTIPW 340
            .|||||.|||.|||.|:..:|.|:|:||:....:||:.:.:|..|:.:   :.|||.:...:.|.
Mouse   113 FMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPV 177

  Fly   341 LLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLI 405
            |....|.|.              |:..|.|.:|....... |.|.||:|.||||:.....||..:
Mouse   178 LALHRLSPG--------------PRTYCSEAFPSRALERA-FALYNLLALYLLPLLATCACYGAM 227

  Fly   406 WIKVSTRSI-PGESKDA-QMDRMQQKS---KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDI 465
            ...:...:: |..:..| |...:.|::   :.||.:::.|||:||...|.|:.:
Mouse   228 LRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQL----------- 281

  Fly   466 SQEEFEILKKVMPVAQW----------------LGSSNSCINPILYS-VNKKYRRGFAAIIKSRS 513
                |.:|:.:.|...|                :..|||.:||:||: :...:|:.|..:.   .
Mouse   282 ----FLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVC---P 339

  Fly   514 CCGRLRYYDNVAIASSTTSTRKSSHYHQNSSR-------KSPSSKGNAV 555
            ||.:.:...:.:..|...:|....|     ||       :|| ..||.|
Mouse   340 CCRQRQRRPHTSAHSDRAATHTVPH-----SRAAHPVRIRSP-EPGNPV 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	94/320 (29%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	16/29 (55%)
		TM helix 4	322..340	CDD:320124	4/20 (20%)
		TM helix 5	379..404	CDD:320124	11/24 (46%)
		TM helix 6	429..459	CDD:320124	9/32 (28%)
		TM helix 7	474..498	CDD:320124	9/40 (23%)
Kiss1r	NP_444474.1	7tmA_KiSS1R	43..334	CDD:320223	96/333 (29%)
		TM helix 1	44..70	CDD:320223	11/38 (29%)
		TM helix 2	77..103	CDD:320223	10/25 (40%)
		TM helix 3	115..145	CDD:320223	16/29 (55%)
		TM helix 4	157..177	CDD:320223	4/19 (21%)
		TM helix 5	201..230	CDD:320223	11/29 (38%)
		TM helix 6	256..286	CDD:320223	10/44 (23%)
		TM helix 7	302..327	CDD:320223	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..396		10/40 (25%)