DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and Npffr2

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_573455.2	Gene:	Npffr2 / 104443	MGIID:	1860130	Length:	417	Species:	Mus musculus

Alignment Length:	335	Identity:	115/335 - (34%)
Similarity:	189/335 - (56%)	Gaps:	16/335 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 SYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTV 242
            |.||:...|.   ..::..:...|.|...::.|:..:|:::|::.::||:.|..:|:|...|.||
Mouse    18 SGNDTQHHWY---SDINITYVNYYLHQPQVAAVFISSYLLIFVLCMVGNTVVCFIVIRNRHMHTV 79

  Fly   243 TNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRF 307
            ||:||:||||:|:||.:||:|.||:.||...|..|..|||....:||:||||||::|:|:::|||
Mouse    80 TNFFILNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRF 144

  Fly   308 IAIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQ--FLCQ 369
            ..:.:|.| ::|.:.|.:.|:.||.:|:....|..:...:  .||.:....:|::::..  :.|:
Mouse   145 RCVVYPFKPKLTVKTAFVTIVIIWGLAIAIMTPSAIMLHV--QEEKYYRVRLSSHNKTSTVYWCR 207

  Fly   370 EVWPPGTDGNLY--FLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKV 432
            |.||......:|  .|.|.:   ||.|:|||.:.|..|...:...:.....|...:.....|.|.
Mouse   208 EDWPRHEMRRIYTTVLFATI---YLAPLSLIVIMYARIGASLFKTAAHCTGKQRPVQWHVSKKKQ 269

  Fly   433 KVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILK-KVMPVAQWLGSSNSCINPILYS 496
            ||||||:.|.:||:||||||:.:.....: :|:|..:..|:. .:.|.|.||...||.:|||:|.
Mouse   270 KVIKMLLTVALLFILSWLPLWTLMMLSDY-TDLSPNKLRIINIYIYPFAHWLAFCNSSVNPIIYG 333

  Fly   497 -VNKKYRRGF 505
             .|:.:|.||
Mouse   334 FFNENFRNGF 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	82/231 (35%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	101/275 (37%)
Npffr2	NP_573455.2	7tm_GPCRs	46..343	CDD:391938	107/302 (35%)
		TM helix 1	48..72	CDD:341315	6/23 (26%)
		TM helix 2	81..103	CDD:341315	13/21 (62%)
		TM helix 3	119..141	CDD:341315	11/21 (52%)
		TM helix 4	162..178	CDD:341315	4/15 (27%)
		TM helix 5	217..240	CDD:341315	9/25 (36%)
		TM helix 6	269..294	CDD:341315	15/24 (63%)
		TM helix 7	311..336	CDD:341315	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850864
Domainoid	1	1.000	176	1.000	Domainoid score	I3599
eggNOG	1	0.900	-	-		E33208_3BBX5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56982
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8802
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.840