DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and npffr1.1

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_004915843.2	Gene:	npffr1.1 / 101733377	XenbaseID:	XB-GENE-987767	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	411	Identity:	136/411 - (33%)
Similarity:	217/411 - (52%)	Gaps:	42/411 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 DFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVI 258
            :|.|...|:||.:::.::.:||..:||:.:|||..|..:||:..:||||||.||:||||:|:||.
Frog    24 NFTFSLYYQHSTSIAAMFILAYTFIFLMCMIGNMLVCFIVLKNRQMRTVTNMFILNLAISDLLVG 88

  Fly   259 VFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ-MTKRRA 322
            :||:|.||:.|:...|....:|||....:||:||:|||::|:|::::||..|.:|.:| :|.|:|
Frog    89 IFCMPTTLVDNLITGWPFDNIMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVYPFRQKLTLRKA 153

  Fly   323 RIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQ--PQFLCQEVWPPGTDGNLY--FL 383
            .|.||.|||:||:...|..:...:...:..|   :|..|:.  |.:.|.|.||......:|  .|
Frog   154 IITIIIIWVLALIIMCPSAVTLTVTKDDFHF---MVDDYNNYYPLYSCWEEWPDTEMRKIYTTVL 215

  Fly   384 LANLVACYLLPMSLITLCYVLIWIKVSTRSIP--GESKDAQMDRMQQKSKVKVIKMLVAVVILFV 446
            .:::   ||.|::||.:.|..|..|:...|.|  |...:....|...|.||:||.||:.|.:.|.
Frog   216 FSHI---YLAPLTLIVIMYARIAFKLFKSSAPIRGSVSEENEGRRVSKRKVRVIYMLIIVALFFS 277

  Fly   447 LSWLPLYVIFARIKFGSDISQEEFEILK-KVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAII 509
            ||||||:.:.....:| .:|..:..::. .|.|.|.||...||.:|||:|. .|:.:||||....
Frog   278 LSWLPLWTLMLLTDYG-HLSDYQLNLIAVYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGFQEAF 341

  Fly   510 KSRSCCGRLRYYDNVAIASSTTSTRKSSHY-----------------HQNSSRKSPSSKGNAVSY 557
            |.:.|..:..:.:       |.|.||:|.:                 .|.|...:.::||...|
Frog   342 KVQVCSMKREHRE-------TYSERKNSGFLFGVRNRIFVEVQPSDSGQGSDSCNSTAKGGMFS- 398

  Fly   558 IYEHNSLRRHNMMLKQDSNLS 578
             .....:..|.::::...|.|
Frog   399 -LRSGRIAHHGLVVEDVDNKS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	89/233 (38%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	105/277 (38%)
npffr1.1	XP_004915843.2	7tmA_NPFFR1	39..337	CDD:320647	114/304 (38%)
		TM helix 1	41..65	CDD:320647	9/23 (39%)
		TM helix 2	74..96	CDD:320647	13/21 (62%)
		TM helix 3	112..134	CDD:320647	10/21 (48%)
		TM helix 4	155..171	CDD:320647	8/15 (53%)
		TM helix 5	209..232	CDD:320647	7/25 (28%)
		TM helix 6	266..288	CDD:320647	11/21 (52%)
		TM helix 7	305..330	CDD:320647	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49256
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000