DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and gpr22b

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_005170723.1	Gene:	gpr22b / 100150048	ZFINID:	ZDB-GENE-141212-234	Length:	440	Species:	Danio rerio

Alignment Length:	429	Identity:	80/429 - (18%)
Similarity:	175/429 - (40%)	Gaps:	110/429 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 ADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYC 212
            |:..|:.....:|:::.:.:.:::||.....|                   ||   |..:|:
Zfish     7 AEEESTMSNVTVLDITESVSPVMTAAGGPYPY-------------------PL---SFQVSL--- 46

  Fly   213 VAYIVVFLV-GLIGNSFVIAV-VLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWM 275
            ..::::.:| ||..|..|:|: .:::..:.:|:|...:||.:.|:||.|.|:|.|::  :.:..:
Zfish    47 TGFLMLEIVLGLSSNLTVLALYCMKSNLVNSVSNIVTMNLHVLDVLVCVCCIPLTIV--VLMLSL 109

  Fly   276 LG--WLMCKFVPYIQGVSVAASVYSLIAVSLDRF-IAIWWPLKQMTKRRARIMIIGIWVIALVT- 336
            .|  .|:|.|.......:..|:..:::|::|||: |::....:.:|..||..::..|||::.|:
Zfish   110 QGDTVLVCCFHEACVSFASVATAANVLAITLDRYDISVKPANRVLTMGRAVALLGCIWVLSFVSF 174

  Fly   337 TIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLC 401
            .:|::....|.|...:.:...|...::..          |:..||:.|...:..:.|...::.:.
Zfish   175 LVPFIEVGFLGPEPTLANQTAVVHVNEYY----------TELGLYYHLVAQIPIFCLTAVIMLMT 229

  Fly   402 YVLIW----IKVSTR-------------------------SIPGESKDAQMD------------- 424
            |..|.    |::.||                         .:| |..||...
Zfish   230 YAKILQALNIRIGTRFHATQKKKKKLRRKKNFSLMSTSEQQLP-EITDASQSSGGTRGNAPLGMR 293

  Fly   425 ----------------RMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEIL 473
                            |.:::.:.:|.:|.:.::..|:|.|.|:.|:...|     :|....::.
Zfish   294 TSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPITVLNTVI-----LSAGPSDLT 353

  Fly   474 KKVMPVAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSR 512
            .|:......:....:..:|:||:..   |:.|..::||:
Zfish   354 VKLRLGFLVMAYGTTVFHPLLYAFT---RQKFQKVLKSK 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	55/290 (19%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	61/332 (18%)
gpr22b	XP_005170723.1	7tm_classA_rhodopsin-like	46..378	CDD:320086	66/352 (19%)
		TM helix 1	46..71	CDD:320086	6/27 (22%)
		TM helix 2	79..105	CDD:320086	10/27 (37%)
		TM helix 3	117..147	CDD:320086	8/29 (28%)
		TM helix 4	158..177	CDD:320086	6/18 (33%)
		TM helix 5	207..232	CDD:320086	5/24 (21%)
		TM helix 6	314..344	CDD:320086	7/29 (24%)
		TM helix 7	354..378	CDD:320086	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100