DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3301 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_001287440.1	Gene:	CG3301 / 42528	FlyBaseID:	FBgn0038878	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	190	Identity:	51/190 - (26%)
Similarity:	83/190 - (43%)	Gaps:	24/190 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VVTGASAGIGAACCRDLVAKGMVVVGLARREKVLQDIKSSLPADQAARFHTRPCDVSNEQ--QVI 72
            ::|||:||:|..........|..:|..|..|.:||.:..:.....|.:......|:::.:  :.:
Human    80 LLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESV 144

  Fly    73 DTFAWIDRTLGGADVLVNN------AGIIRQMNITDPENSADVRAILDVNVLGVTWCTRQWFLSL 131
            ..|| :|: |||.|.||.|      ||       |...:....|.::.||.:.....|.:...||
Human   145 VQFA-LDK-LGGLDYLVLNHIGGAPAG-------TRARSPQATRWLMQVNFVSYVQLTSRALPSL 200

  Fly   132 QRRKVNDGHVVVINSVVGHSVPAVEGFSLNMYAPSKHAITALTEILRQEFIKKGTQTKIT 191
            ...|   |.:||::|::|. ||.  .|| ..|:.:|.|:......||:|...:.....||
Human   201 TDSK---GSLVVVSSLLGR-VPT--SFS-TPYSAAKFALDGFFGSLRRELDVQDVNVAIT 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3301	NP_001287440.1	YdfG	1..250	CDD:226674	51/190 (27%)
CG3301	NP_001287440.1	NADB_Rossmann	1..245	CDD:304358	51/190 (27%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	51/190 (27%)
		PRK08251	78..302	CDD:181324	51/190 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900