DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-2sigma and AP4S1

DIOPT Version :9

Sequence 1:	NP_650961.2	Gene:	AP-2sigma / 42525	FlyBaseID:	FBgn0043012	Length:	142	Species:	Drosophila melanogaster
Sequence 2:	NP_009008.2	Gene:	AP4S1 / 11154	HGNCID:	575	Length:	159	Species:	Homo sapiens

Alignment Length:	140	Identity:	51/140 - (36%)
Similarity:	82/140 - (58%)	Gaps:	11/140 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRFILIQNRAGKTRLAKWYMNFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIVYRRYAGL 65
            ||:|.|:.|:.|:|||:|:|.:.|.:::..|..||......|..:..:|:|:::||::||:||.|
Human     1 MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAAL 65

  Fly    66 YFCICVDVNDNNLCYLEAIHNFVEVLNEYFHNVCELDL-VFN--FYKVYSV--------VDEMFL 119
            :..:.|:..:|.:...|.||||||||:|||..|.|||: .||  |:..:.:        :||:..
Human    66 FIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDVSFFNTVFHSTWQMHSGPYQEPIDELPK 130

  Fly   120 AGEIRETSQT 129
            .....|..||
Human   131 ICSALEPQQT 140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2sigma	NP_650961.2	AP2_sigma	1..141	CDD:341437	51/140 (36%)
AP4S1	NP_009008.2	Clat_adaptor_s	1..>105	CDD:261170	43/103 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53551
OrthoDB	1	1.010	-	-		D1307450at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930