DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab1 and RAB33B

DIOPT Version :9

Sequence 1:	NP_732610.1	Gene:	Rab1 / 42524	FlyBaseID:	FBgn0285937	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_011530601.1	Gene:	RAB33B / 83452	HGNCID:	16075	Length:	277	Species:	Homo sapiens

Alignment Length:	174	Identity:	74/174 - (42%)
Similarity:	113/174 - (64%)	Gaps:	5/174 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQ 70
            |....:||:::||||.|||:||..||....:.:...:||||||:.|.:|:||:.||:|:||||||
Human    76 PARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQ 140

  Fly    71 ERFR-TITSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACEN-VNKLLVGNKSDLTTKKV 133
            |||| ::...|||..|.::.|||.|:..||:::..|:||.:::...| :.::|||||.||.:...
Human   141 ERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQ 205

  Fly   134 VDHTTAAEYAAQLGIPFLETSAKSAT---NVEQAFMTMAAEIKN 174
            |....|.::|....:|..|||||:..   :||..|||:|.::|:
Human   206 VPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKS 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	73/170 (43%)
RAB33B	XP_011530601.1	Rab33B_Rab33A	80..249	CDD:133315	72/168 (43%)
RAB33B	XP_011530601.1	RAB	82..248	CDD:197555	72/165 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810