DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab1 and RAB1B

DIOPT Version :9

Sequence 1:	NP_732610.1	Gene:	Rab1 / 42524	FlyBaseID:	FBgn0285937	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_016873867.1	Gene:	RAB1B / 81876	HGNCID:	18370	Length:	237	Species:	Homo sapiens

Alignment Length:	238	Identity:	168/238 - (70%)
Similarity:	181/238 - (76%)	Gaps:	37/238 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTA 68
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human     1 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTA 65

  Fly    69 GQERFRTITSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACENVNKLLVGNKSDLTTKKV 133
            ||||||||||||||||||||||||.|||||:.||||||:||:|||.|||||||||||||||||||
Human    66 GQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKV 130

  Fly   134 VDHTTA------------------------------------AEYAAQLGIPFLETSAKSATNVE 162
            ||:|||                                    .|:|..|||||||||||:|||||
Human   131 VDNTTAKVADGPVCPGSGRWGLLPLTCSPLLFSPLLFSPLPCQEFADSLGIPFLETSAKNATNVE 195

  Fly   163 QAFMTMAAEIKNRVGPPSSATDNASKVKIDQGRPVENTKSGCC 205
            |||||||||||.|:||.:::......:||| ..||:....|||
Human   196 QAFMTMAAEIKKRMGPGAASGGERPNLKID-STPVKPAGGGCC 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	152/200 (76%)
RAB1B	XP_016873867.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1466
eggNOG	1	0.900	-	-		E1_KOG0084
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2359
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1149105at2759
OrthoFinder	1	1.000	-	-		FOG0001193
OrthoInspector	1	1.000	-	-		otm41004
orthoMCL	1	0.900	-	-		OOG6_101123
Panther	1	1.100	-	-	O	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1997
SonicParanoid	1	1.000	-	-		X737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860