Protein Alignment Rab1 and RAB1B

DIOPT Version :10

• Sequence 1: NP_732610.1
• Gene: Rab1 / 42524
• FlyBaseID: FBgn0285937
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 168/202 - (83%)
• Similarity: 181/202 - (89%)
• Gaps: 1/202 - (0%)

  Fly     4 VNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTA 68
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human     1 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTA 65

  Fly    69 GQERFRTITSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACENVNKLLVGNKSDLTTKKV 133
            ||||||||||||||||||||||||.|||||:.||||||:||:|||.|||||||||||||||||||
Human    66 GQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKV 130

  Fly   134 VDHTTAAEYAAQLGIPFLETSAKSATNVEQAFMTMAAEIKNRVGPPSSATDNASKVKIDQGRPVE 198
            ||:|||.|:|..|||||||||||:||||||||||||||||.|:||.:::......:||| ..||:
Human   131 VDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKID-STPVK 194

  Fly   199 NTKSGCC 205
            ....|||
Human   195 PAGGGCC 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	152/164 (93%)
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	152/164 (93%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		14/14 (100%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		18/18 (100%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		14/14 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		8/27 (30%)