Protein Alignment Rab1 and RAB6A

DIOPT Version :10

• Sequence 1: NP_732610.1
• Gene: Rab1 / 42524
• FlyBaseID: FBgn0285937
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 74/195 - (37%)
• Similarity: 120/195 - (61%)
• Gaps: 4/195 - (2%)

  Fly    12 FKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTI 76
            |||:.:|:..|||:.|:.||..|::..:|.:|||:||..:|:.|:.:||:||:||||||||||::
Human    14 FKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSL 78

  Fly    77 TSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACENVNKLLVGNKSDLTTKKVVDHTTAAE 141
            ..||.|.:...:||||.|:..||....:|::::......:|..:|||||:||..|:.|.......
Human    79 IPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGER 143

  Fly   142 YAAQLGIPFLETSAKSATNVEQAFMTMAAEIKNRVGPPSSATDNASKVKID--QGRPVENTKSGC 204
            .|.:|.:.|:|||||:..||:|.|..:||.:.........:.::...:|::  |.:||  ::.||
Human   144 KAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPV--SEGGC 206

  Fly   205  204
            Human   207  206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	68/162 (42%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	68/159 (43%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		7/17 (41%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		11/18 (61%)