Protein Alignment Rab1 and RAB5A

DIOPT Version :10

• Sequence 1: NP_732610.1
• Gene: Rab1 / 42524
• FlyBaseID: FBgn0285937
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 86/195 - (44%)
• Similarity: 122/195 - (62%)
• Gaps: 3/195 - (1%)

  Fly    12 FKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTI 76
            |||:|:|:|.||||.|:|||....:.|...||||..|..:|:.||..|:|.:|||||||||:.::
Human    21 FKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSL 85

  Fly    77 TSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACENVNKLLVGNKSDLTTKKVVDHTTAAE 141
            ...|||||...|||||.|::|||...|.|::|::|.|..|:...|.|||:||..|:.||...|..
Human    86 APMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQS 150

  Fly   142 YAAQLGIPFLETSAKSATNVEQAFMTMAAEI-KNRVGPPSSATDNASKVKIDQGRPVENTKSGCC 205
            ||....:.|:|||||::.||.:.||.:|.:: ||.  |.:...::|....:|...|.:.|::.||
Human   151 YADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNE--PQNPGANSARGRGVDLTEPTQPTRNQCC 213

  Fly   206  205
            Human   214  213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	78/163 (48%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	77/160 (48%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		5/11 (45%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		8/15 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		9/35 (26%)