DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab1 and RABL6

DIOPT Version :9

Sequence 1:	NP_732610.1	Gene:	Rab1 / 42524	FlyBaseID:	FBgn0285937	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_001167459.1	Gene:	RABL6 / 55684	HGNCID:	24703	Length:	730	Species:	Homo sapiens

Alignment Length:	151	Identity:	32/151 - (21%)
Similarity:	67/151 - (44%)	Gaps:	32/151 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT----IKLQIWDTAGQ 70
            |..|:::.||...||:.|..|.....:.|.||.|  .:.::.:|....||    :|:::||...:
Human    42 YNMKIVIRGDRNTGKTALWHRLQGRPFVEEYIPT--QEIQVTSIHWSYKTTDDIVKVEVWDVVDK 104

  Fly    71 -------------------ERFRTITSSY---YRGAHGIIVVYDCTDQESFNNVKQWLEEIERYA 113
                               |....:.:.:   |:..:|:::::|.|.|.:||.:.:.|.::..:
Human   105 GKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTH- 168

  Fly   114 CENVNKLLVGNKSDLTTKKVV 134
               |...::||..|:...:|:
Human   169 ---VPVCVLGNYRDMGEHRVI 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	32/151 (21%)
RABL6	NP_001167459.1	P-loop_NTPase	44..222	CDD:304359	31/149 (21%)
		Ras	45..222	CDD:278499	31/148 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..730
		Interaction with CDKN2A. /evidence=ECO:0000269\|PubMed:16582619	656..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900