Protein Alignment Rab1 and RAB37

DIOPT Version :10

• Sequence 1: NP_732610.1
• Gene: Rab1 / 42524
• FlyBaseID: FBgn0285937
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_001006639.1
• Gene: RAB37 / 326624
• HGNCID: 30268
• Length: 223
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 86/207 - (41%)
• Similarity: 135/207 - (65%)
• Gaps: 15/207 - (7%)

  Fly     5 NPEYDYLFKLLLIGDSGVGKSCLLLRFADDTY-TESYISTIGVDFKIRTIELDGKTIKLQIWDTA 68
            :|.||...|::|:||:||||:|.|::|.|..: :.::|:|:|:||:.:.:.:||..:||||||||
Human    23 SPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTA 87

  Fly    69 GQERFRTITSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIERYACENVNKLLVGNKSDLTTKKV 133
            ||||||::|.:|||.|..::::||.|::.||:|::.||.||..||..:|..:|:|||:|:::::|
Human    88 GQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADMSSERV 152

  Fly   134 VDHTTAAEYAAQLGIPFLETSAKSATNVEQAFMTMAAEIKNRVG-----PPSSATDNASKVKIDQ 193
            :........|.:.|:||||||||:..|||.||:.:|.|:|.|.|     |.....|.....|
Human   153 IRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYVESQK--- 214

  Fly   194 GRPVENTKSGCC 205
                  .:|.||
Human   215 ------KRSSCC 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	75/165 (45%)
RAB37	NP_001006639.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		86/207 (42%)
		Rab26	31..220	CDD:206695	81/197 (41%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	52..67		3/14 (21%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	85..102		12/16 (75%)