Protein Alignment Rab1 and RAB32

DIOPT Version :10

• Sequence 1: NP_732610.1
• Gene: Rab1 / 42524
• FlyBaseID: FBgn0285937
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_006825.1
• Gene: RAB32 / 10981
• HGNCID: 9772
• Length: 225
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 67/204 - (32%)
• Similarity: 112/204 - (54%)
• Gaps: 8/204 - (3%)

  Fly     9 DYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT-IKLQIWDTAGQER 72
            ::|||:|:||:.||||:.::.|:....:::.|.:||||||.::.:..|.:| ::||:||.|||||
Human    23 EHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQER 87

  Fly    73 FRTITSSYYRGAHGIIVVYDCTDQESFNNVKQWLEEIE-RYACEN---VNKLLVGNKSDLTTKKV 133
            |..:|..||:.|.|..||:|.:...:|..|.:|..::: :....|   :..:|:.||.|......
Human    88 FGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQNKDSS 152

  Fly   134 VDHTTAAEYAAQLGIP-FLETSAKSATNVEQAFMTMAAEI-KNRVGPPSSATDNASKVKIDQGRP 196
            ...:...::..:.|.. :.|||||...|:|:|...:..:| .|....|:...| ..|:|:||...
Human   153 QSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKILVNHQSFPNEEND-VDKIKLDQETL 216

  Fly   197 VENTKSGCC 205
            ....||.||
Human   217 RAENKSQCC 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab1	NP_732610.1	Rab1_Ypt1	10..175	CDD:206661	56/171 (33%)
RAB32	NP_006825.1	Rab32_Rab38	26..224	CDD:206692	64/198 (32%)
		Switch 1. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	48..62		5/13 (38%)
		Switch 2. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	84..97		7/12 (58%)
		PKA-RII subunit binding domain	178..197		5/18 (28%)