Protein Alignment ETHR and TRHR

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_003292.1
• Gene: TRHR / 7201
• HGNCID: 12299
• Length: 398
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 108/342 - (31%)
• Similarity: 169/342 - (49%)
• Gaps: 73/342 - (21%)

  Fly    10 RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVLVEVNT 73
            :...:...::|..||:|||:||.:|:::||.||..||.:|.:|::|||:||:.. .|.:...:.
Human    25 QVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIY- 88

  Fly    74 RPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWG 138
              .:||.|:..|..:.:::....:||..:|.|.:.|||.|||.|:||.::||..||..|.:..|.
Human    89 --GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWA 151

  Fly   139 IAALFTSPILW--VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGI 201
            ..:|:.  :||  :.:..::.|.| :.|..|..:...::....:||...||:|||.:...||||.
Human   152 FTSLYC--MLWFFLLDLNISTYKD-AIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGF 213

  Fly   202 IARNLVSNRAAMLRARPTKPELSLK---------------------------ARKQVVLMLGAVV 239
            |||.|      .|...|:.|:.:.|                           :||||..||..||
Human   214 IARIL------FLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVV 272

  Fly   240 LSFFVCLLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNSAMNPI 292
            :.|.:..:|:|.|.:            |.:|                   ||||.:|||||:||:
Human   273 ILFALLWMPYRTLVVVNSFLSSPFQENWFLL-------------------FCRICIYLNSAINPV 318

  Fly   293 LYNLMSTKFRRGFKRLC 309
            :|||||.|||..|::||
Human   319 IYNLMSQKFRAAFRKLC 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	105/335 (31%)
		TM helix 1	12..38	CDD:320128	9/25 (36%)
		TM helix 2	45..70	CDD:320128	10/25 (40%)
		TM helix 3	85..115	CDD:320128	9/29 (31%)
		TM helix 4	128..149	CDD:320128	5/20 (25%)
		TM helix 5	176..205	CDD:320128	13/28 (46%)
		TM helix 6	226..256	CDD:320128	13/68 (19%)
		TM helix 7	273..298	CDD:320128	14/24 (58%)
TRHR	NP_003292.1	7tmA_TRH-R	26..331	CDD:320126	105/335 (31%)
		TM helix 1	27..53	CDD:320126	9/25 (36%)
		TM helix 2	60..85	CDD:320126	10/24 (42%)
		TM helix 3	98..128	CDD:320126	9/29 (31%)
		TM helix 4	141..162	CDD:320126	7/22 (32%)
		TM helix 5	188..217	CDD:320126	13/28 (46%)
		TM helix 6	259..289	CDD:320126	12/29 (41%)
		TM helix 7	299..324	CDD:320126	16/43 (37%)