DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and TRHR

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_003292.1	Gene:	TRHR / 7201	HGNCID:	12299	Length:	398	Species:	Homo sapiens

Alignment Length:	342	Identity:	108/342 - (31%)
Similarity:	169/342 - (49%)	Gaps:	73/342 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVLVEVNT 73
            :...:...::|..||:|||:||.:|:::||.||..||.:|.:|::|||:||:.. .|.:...:.
Human    25 QVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIY- 88

  Fly    74 RPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWG 138
              .:||.|:..|..:.:::....:||..:|.|.:.|||.|||.|:||.::||..||..|.:..|.
Human    89 --GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWA 151

  Fly   139 IAALFTSPILW--VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGI 201
            ..:|:.  :||  :.:..::.|.| :.|..|..:...::....:||...||:|||.:...||||.
Human   152 FTSLYC--MLWFFLLDLNISTYKD-AIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGF 213

  Fly   202 IARNLVSNRAAMLRARPTKPELSLK---------------------------ARKQVVLMLGAVV 239
            |||.|      .|...|:.|:.:.|                           :||||..||..||
Human   214 IARIL------FLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVV 272

  Fly   240 LSFFVCLLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNSAMNPI 292
            :.|.:..:|:|.|.:            |.:|                   ||||.:|||||:||:
Human   273 ILFALLWMPYRTLVVVNSFLSSPFQENWFLL-------------------FCRICIYLNSAINPV 318

  Fly   293 LYNLMSTKFRRGFKRLC 309
            :|||||.|||..|::||
Human   319 IYNLMSQKFRAAFRKLC 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	46/125 (37%)
		7tm_1	27..294	CDD:278431	93/308 (30%)
		7tm_4	<102..307	CDD:304433	77/245 (31%)
TRHR	NP_003292.1	7tmA_TRH-R	26..331	CDD:320126	105/335 (31%)
		TM helix 1	27..53	CDD:320126	9/25 (36%)
		TM helix 2	60..85	CDD:320126	10/24 (42%)
		TM helix 3	98..128	CDD:320126	9/29 (31%)
		TM helix 4	141..162	CDD:320126	7/22 (32%)
		TM helix 5	188..217	CDD:320126	13/28 (46%)
		TM helix 6	259..289	CDD:320126	12/29 (41%)
		TM helix 7	299..324	CDD:320126	16/43 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4774
eggNOG	1	0.900	-	-		E33208_3BFHW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4133
Isobase	1	0.950	-	0	Normalized mean entropy	S5306
OMA	1	1.010	-	-		QHG46032
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	1	1.000	-	-		oto91666
orthoMCL	1	0.900	-	-		OOG6_104289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4203
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.750