DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and trhr2

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_005159153.1	Gene:	trhr2 / 556431	ZFINID:	ZDB-GENE-050419-193	Length:	498	Species:	Danio rerio

Alignment Length:	441	Identity:	130/441 - (29%)
Similarity:	206/441 - (46%)	Gaps:	88/441 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVLVEVNT 73
            :|.::|..:::..:|:|||:||.:|::.|:.||..||.:|.:|::|||:||:.. .|.:...:..
Zfish    32 KTVSVFLVLLVCGVGIVGNIMVVLVVLTTRHMRTPTNCYLVSLAVADLMVLVAAGLPNISESLMA 96

  Fly    74 RPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWG 138
               |||.||..|..:.:.:....:||..:|.|.:.|||.|||.|::|..|||..||..|..:.|.
Zfish    97 ---TWVYGHAGCLGITYFQYLGINASSCSITAFTVERYIAICHPMRAQTVCTVSRAKRIIAVVWV 158

  Fly   139 IAALFTSPILWVAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGIIA 203
            ...::.  :||:....:....||.  ..|..:...|..|..:|:..::|:|:|.:..:.|||:||
Zfish   159 FTCVYC--MLWLFLVDIQVNPDGR--VQCGYRVSRDLYLPIYLIDFTIFYVIPLLLAIALYGLIA 219

  Fly   204 RNLVSNR-----------AAMLR------------ARPTKPELSLKARKQVVLMLGAVVLSFFVC 245
            |.|..|.           |..||            .|..:|:.:|.:||||..||..||:.|.:.
Zfish   220 RILYLNPLPHPPDSGTVIAPTLRRSCKEPADGGKAIRQGRPKSALSSRKQVTKMLAVVVVLFALL 284

  Fly   246 LLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNSAMNPILYNLMS 298
            .:|:|.|.|            |.||                   |||..:|.|||:||::|||||
Zfish   285 WMPYRTLVLINSFVSTPYLDSWFIL-------------------FCRTCIYANSAINPVVYNLMS 330

  Fly   299 TKFRRGFKRL--C--QDAGRLLLELV----TLGRRKEDSSRGRRGT-LSLGMGT----------N 344
            .|||..|:.|  |  :|..:..|.::    :|||.....|.|.|.| ..:|..|          |
Zfish   331 QKFRSAFRGLYRCRREDLHQRTLSMLQSGYSLGRDPRICSNGTRDTPKKVGSVTPEQKQNKGFEN 395

  Fly   345 TNTNTNSSNATGATS--SSILSRSSNRRCSEDISRTRLKIEMQMPCGSDLE 393
            ...||:...:.|..:  :..:.:::...|..|.|:|     .:||...|::
Zfish   396 KVENTDRQISDGVENEINPSIKKNACANCDIDESKT-----SEMPTVEDVD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	45/125 (36%)
		7tm_1	27..294	CDD:278431	93/302 (31%)
		7tm_4	<102..307	CDD:304433	76/239 (32%)
trhr2	XP_005159153.1	7tm_4	40..>169	CDD:304433	47/133 (35%)
trhr2	XP_005159153.1	7tm_1	49..326	CDD:278431	93/302 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFHW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4086
OMA	1	1.010	-	-		QHG46032
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	1	1.000	-	-		otm24868
orthoMCL	1	0.900	-	-		OOG6_104289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.770