Protein Alignment ETHR and PK1-R

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_001014620.1
• Gene: PK1-R / 41713
• FlyBaseID: FBgn0038201
• Length: 430
• Species: Drosophila melanogaster
• Alignment Length: 407
• Identity: 115/407 - (28%)
• Similarity: 184/407 - (45%)
• Gaps: 76/407 - (18%)

  Fly    19 VIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVEVNTRPETWVLGHE 83
            :|.:.|||||:...|||.|.:.|..:||.:|.:|:|:|.|:||...|..:..:.:: ..:|.|..
  Fly    29 LIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSYIWSK-YPYVFGEY 92

  Fly    84 MCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWGIAALFTSPIL 148
            :|.....:..|.|:|:||||.|.:.|||.|||.|.....:....|||.|.||.| |.|:.|: |.
  Fly    93 ICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVLVW-IMAIVTA-IP 155

  Fly   149 WVAEYKLAEYIDGSSVAVC-LTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGIIARNLVSN--- 209
            ..|::.:..|   |.|..| :.:.|...:   |.::..:||:.|...::|||.:|..:|..:
  Fly   156 QAAQFGIEHY---SGVEQCGIVRVIVKHS---FQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLV 214

  Fly   210 -------RAAMLRARPTKPEL---------------------------------SLKAR------ 228
                   |...|::.|:...|                                 |::.|
  Fly   215 EGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGT 279

  Fly   229 KQVVLMLGAVVLSFFVCLLPFRVLTLWIILSTDQ--TLHDLGLVRYYSLLYFCRIMLYLNSAMNP 291
            ::|:.||.|||:.||:|..||....|..|.:..:  .|.|.....|..:.|...::.||::.:||
  Fly   280 RRVLRMLVAVVVCFFLCWAPFHAQRLIAIYAPARGAKLRDQHEFVYTVMTYVSGVLYYLSTCINP 344

  Fly   292 ILYNLMSTKFRRGFKRLCQDAGRLLLELVTLG----RRKEDSSRGRRGTLSLGMGTNTNTNTNSS 352
            :|||:||.|||..||.:      |..:.|:.|    |...:|.|.||     .:..::.|...|.
  Fly   345 LLYNIMSHKFREAFKAV------LFGKKVSKGSLNSRNNIESRRLRR-----ALTNSSQTQRFSI 398

  Fly   353 NATGATSSSILSRSSNR 369
            .:......||:...:|:
  Fly   399 ESAEQPKPSIMQNPTNK 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	100/337 (30%)
		TM helix 1	12..38	CDD:320128	9/18 (50%)
		TM helix 2	45..70	CDD:320128	10/24 (42%)
		TM helix 3	85..115	CDD:320128	13/29 (45%)
		TM helix 4	128..149	CDD:320128	11/20 (55%)
		TM helix 5	176..205	CDD:320128	8/28 (29%)
		TM helix 6	226..256	CDD:320128	13/35 (37%)
		TM helix 7	273..298	CDD:320128	8/24 (33%)
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	100/337 (30%)
		TM helix 1	21..48	CDD:320262	9/18 (50%)
		TM helix 2	55..81	CDD:320262	10/25 (40%)
		TM helix 3	94..124	CDD:320262	13/29 (45%)
		TM helix 4	136..158	CDD:320262	11/23 (48%)
		TM helix 5	178..207	CDD:320262	8/31 (26%)
		TM helix 6	277..307	CDD:320262	12/29 (41%)
		TM helix 7	326..351	CDD:320262	8/24 (33%)