Protein Alignment ETHR and PK2-R1

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 394
• Identity: 109/394 - (27%)
• Similarity: 182/394 - (46%)
• Gaps: 62/394 - (15%)

  Fly    12 TAMFFC-IVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVEVNTRP 75
            ||:..| .:|.:.||:||::..|||.:...|..:||.:|.||:::||::|:...|..|..: ..|
  Fly   108 TALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNL-WYP 171

  Fly    76 ETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWGIA 140
            :.:.....||.....:....|:|:||||.|.:.|||.|||.|.:...:....|||......|..|
  Fly   172 DMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAA 236

  Fly   141 ALFTSPILWVAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGIIARN 205
            .|...|  ...::.:....:|.|   |..:  :|:....|.::..:||..|...:.|||.:|...
  Fly   237 FLLALP--QAMQFSVVYQNEGYS---CTME--NDFYAHVFAVSGFIFFGGPMTAICVLYVLIGVK 294

  Fly   206 LVSNRAAMLRARPTK---PELSLKARKQVVLMLGAVVLSFFVCLLPFRVLTLWIILSTDQTLHDL 267
            |  .|:.:|::.|.:   ....|.|:.:|:.||.||.::||:|..||....|..:...:  |.::
  Fly   295 L--KRSRLLQSLPRRTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLN--LINI 355

  Fly   268 GLVR-----YYSLL-YFCRIMLYLNSAMNPILYNLMSTKFRRGFKRLCQDAGRLLLELVTLGRRK 326
            |:.|     |:.:| |...::.:|::.:||:|||:||.|||..||             :||.|:
  Fly   356 GISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFK-------------ITLTRQ- 406

  Fly   327 EDSSRGRRGTLSLGMGTNTNTNTNSSNATGATSSSILSRSSNRR-----CSEDISRTRLKIEMQM 386
                          .|...|.:...|.......|::|.::.:.|     ||  ::...|:
  Fly   407 --------------FGLARNHHHQQSQHHQHNYSALLRQNGSMRLQPASCS--VNNNALE----- 450

  Fly   387 PCGS 390
            |.||
  Fly   451 PYGS 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	92/302 (30%)
		TM helix 1	12..38	CDD:320128	11/26 (42%)
		TM helix 2	45..70	CDD:320128	10/24 (42%)
		TM helix 3	85..115	CDD:320128	12/29 (41%)
		TM helix 4	128..149	CDD:320128	7/20 (35%)
		TM helix 5	176..205	CDD:320128	8/28 (29%)
		TM helix 6	226..256	CDD:320128	12/29 (41%)
		TM helix 7	273..298	CDD:320128	8/25 (32%)
PK2-R1	NP_731790.1	7tmA_capaR	108..399	CDD:320262	92/302 (30%)
		TM helix 1	108..135	CDD:320262	11/26 (42%)
		TM helix 2	142..168	CDD:320262	10/25 (40%)
		TM helix 3	181..211	CDD:320262	12/29 (41%)
		TM helix 4	223..245	CDD:320262	7/23 (30%)
		TM helix 5	265..294	CDD:320262	8/28 (29%)
		TM helix 6	316..346	CDD:320262	12/29 (41%)
		TM helix 7	367..392	CDD:320262	8/24 (33%)